Results 51 to 60 of about 5,293,267 (352)
Rheumatology, 2016 Objectives : Methotrexate (MTX) is one of the most frequently used, highly effective disease-modifying drugs in juvenile idiopathic arthritis (JIA) therapy.
Zbigniew Żuber +6 more
doaj +1 more source
Broncho-Vaxom attenuates allergic airway inflammation by restoring GSK3β-related T regulatory cell insufficiency. [PDF]
PLoS ONE, 2014 Oral administration of bacterial extracts (eg, Broncho-Vaxom (BV)) has been proposed to attenuate asthma through modulating Treg cells. However, the underlying mechanism has not been fully characterized.
Ran Fu +8 more
doaj +1 more source
A case of rhinoscleroma treated with ciprofloxacin [PDF]
, 2001 Respiratory scleroma (often termed \'rhinoscleroma\') is a chronic inflammatory condition in which deforming masses of tissue distend the nasal cavity. Klebsiella rhinoscleromatis is the causative agent of this infection and the Mikulicz cell is specific
Badia, L, Lund, VJ
core +1 more source
Nanomedicine for increasing the oral bioavailability of cancer treatments
Journal of Nanobiotechnology, 2021 Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications ...
A. Parodi +7 more
semanticscholar +1 more source
Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs [PDF]
Pharmaceutics, 2018 Current strategies for the mass administration of antimalarial drugs demand oral formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas recommendations for future interventions stress the importance of also targeting the transmission stages of the parasite as it passes between humans and mosquitoes.
Coma-Cros, Elisabet Martí +19 more
openaire +10 more sources
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs
Pharmaceutics, 2018 Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional ...
Jeong-Soo Kim, Min-Soo Kim, In-hwan Baek
doaj +1 more source
Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice [PDF]
, 2019 Background With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects.
Boehm, Stephen L., II +3 more
core +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Pharmacokinetic Interaction Between Oltipraz and Silymarin in Rats
Journal of Pharmacy & Pharmaceutical Sciences, 2009 . Purpose: To evaluate the pharmacokinetic interaction between oltipraz and silymarin after intravenous and oral administration of both drugs to male Sprague–Dawley rats.
Min Kyung Kang +3 more
doaj +1 more source