Results 51 to 60 of about 5,122,356 (332)
Pharmacokinetics and Tissue Distribution of Enavogliflozin in Mice and Rats
Pharmaceutics, 2022 This study investigated the pharmacokinetics and tissue distribution of enavogliflozin, a novel sodium-glucose cotransporter 2 inhibitor that is currently in phase three clinical trials.
Minyeong Pang +6 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Pharmacokinetic Interaction Between Oltipraz and Silymarin in Rats
Journal of Pharmacy & Pharmaceutical Sciences, 2009 . Purpose: To evaluate the pharmacokinetic interaction between oltipraz and silymarin after intravenous and oral administration of both drugs to male Sprague–Dawley rats.
Min Kyung Kang +3 more
doaj +1 more source
Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers
Biomolecules, 2022 Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients.
Yangqi Zhou +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
Effect of Oral Antacid Administration on the Pharmacokinetics of Oral Fluconazole [PDF]
Antimicrobial Agents and Chemotherapy, 1990 Absorption and elimination of fluconazole after oral administration of a 100-mg capsule were unaffected by concomitant administration of an antacid containing aluminum and magnesium hydroxides.
Maguy Bromet-Petit +2 more
openaire +3 more sources
Advances in the pharmaceutical research of curcumin for oral administration
Open Chemistry, 2023 Curcumin is an isolated phytopolyphenol pigment found in the Curcuma longa, commonly known as turmeric, with various pharmacological properties.
Li Cheng +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Pharmaceutics, 2019 Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects.
B. Homayun, Xueting Lin, Hyo-Jick Choi
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source