Results 61 to 70 of about 326,995 (379)

Lung cancer immunotherapy: progress, pitfalls, and promises

Molecular Cancer, 2023
Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery, radiation therapy, chemotherapy, and targeted drug therapy.
Aritraa Lahiri, Avik Maji, P. Potdar, Navneet Singh, P. Parikh, B. Bisht, Anubhab Mukherjee, M. Paul   +7 more
semanticscholar   +1 more source

Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients [PDF]

, 2013
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients
Klingebiel, Thomas, Lehrnbecher, Thomas, Schmidt, Stanislaw, Tramsen, Lars   +3 more
core   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Autotransplantation of T-lymphocytes as a tool for antigen-specific immunotherapy of oncological diseases

Вестник трансплантологии и искусственных органов, 2018
Autotransplantation of immune cells to induce immunological rejection of tumors can be a useful approach in tumor treatment. Despite the low efficiency of this  approach demonstrated in the past, the active development of cell technologies and  genetic ...
A. Yu. Lupatov, P. A. Karalkin, A. A. Boyko, K. N. Yarygin   +3 more
doaj   +1 more source

Immune evasion in cancer: mechanistic basis and therapeutic strategies [PDF]

, 2015
Cancer immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Although considerable progress has been made in understanding how cancers evade destructive immunity, measures to counteract tumor escape have not ...
Amin, Amr, Aquilano, Katia, Ashraf, S. Salman, Azmi, Asfar S., Bhakta, Dipita, Bilsland, Alan, Boosani, Chandra S., Chen, Sophie, Choi, Beom K., Ciriolo, Maria Rosa, Decker, William K., Elkord, Eyad, Fujii, Hiromasa, Georgakilas, Alexandros G., Guha, Gunjan, Halicka, Dorota, Helferich, William G., Honoki, Kanya, Keith, W. Nicol, Kumara, H.M.C. Shantha, Kwona, Byoung S., Lichtor, Terry, Mohammed, Sulma I., Nowsheen, Somaira, Pawelec, Graham, Ryan, Elizabeth P., Signori, Emanuela, Stagg, John, Talib, Wamidh H., Vinay, Dass S., Whelan, Richard L., Yang, Xujuan   +31 more
core   +1 more source

Generation and application of human induced‐stem cell memory T cells for adoptive immunotherapy

Cancer Science, 2018
Adoptive T‐cell therapy is an effective strategy for cancer immunotherapy. However, infused T cells frequently become functionally exhausted, and consequently offer a poor prognosis after transplantation into patients.
T. Kondo, Y. Imura, S. Chikuma, Sana Hibino, Setsuko Omata-Mise, M. Ando, Takashi Akanuma, M. Iizuka, R. Sakai, R. Morita, A. Yoshimura   +10 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

Journal for ImmunoTherapy of Cancer, 2017
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors.
Irene Scarfò, Marcela V. Maus
doaj   +1 more source

Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting

Nature Communications, 2021
KRAS is commonly mutated at codon 12 in several cancer types, offering a unique opportunity for the development of neoantigen-targeted immunotherapy. Here the authors present a pipeline for the prediction, identification and validation of HLA class-I ...
Adham S. Bear, Tatiana Blanchard, Joseph Cesare, Michael J. Ford, Lee P. Richman, Chong Xu, Miren L. Baroja, Sarah McCuaig, Christina Costeas, Khatuna Gabunia, John Scholler, Avery D. Posey, Mark H. O’Hara, Anze Smole, Daniel J. Powell, Benjamin A. Garcia, Robert H. Vonderheide, Gerald P. Linette, Beatriz M. Carreno   +18 more
doaj   +1 more source

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

Nature Communications, 2018
Adoptive T-cell therapy is a promising therapeutic approach for cancer patients. The use of allogeneic T-cell grafts will improve its applicability and versatility provided that inherent allogeneic responses are controlled.
Yuki Kagoya, M. Nakatsugawa, Kayoko Saso, Tingxi Guo, M. Anczurowski, Chung-Hsi Wang, M. Butler, C. Arrowsmith, N. Hirano   +8 more
semanticscholar   +1 more source