Results 151 to 160 of about 57,324 (252)

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

A CD22-specific T-cell receptor enables effective adoptive T-cell therapy for B-cell malignancies. [PDF]

Blood
Rhein S, Çakmak-Görür N, Grunert C, Al-Tabatabaee S, Serin N, Leisegang M, Timiliotis S, Ohlmeier L, Freund C, Willimsky G, Konietschke F, Kieback E, Tasian SK, Chapuy B, Keller U, Blankenstein T, Pezzutto A, Busse A.   +17 more
europepmc   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

152 Adoptive T cell therapy targeting somatic p53 mutations

Journal for ImmunoTherapy of Cancer, 2020
Nikolaos Zacharakis, Parisa Malekzadeh, Peter Kim, Nolan Vale, Elizabeth Hedges   +4 more
doaj   +1 more source

Protease-Activated Plasmonic Nanosensors for Predictive Ultrasound-Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy. [PDF]

Adv Sci (Weinh)
Kim M, Song S, Zamat A, Pelkowski PS, Subramanian S, Cadena M, Fabrega S, Brienen M, Kim J, Kwong GA, Emelianov SY.   +10 more
europepmc   +1 more source

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion. [PDF]

J Immunother Cancer, 2023
Teagle AR, Castro-Sanchez P, Brownlie RJ, Logan N, Kapoor SS, Wright D, Salmond RJ, Zamoyska R.   +7 more
europepmc   +1 more source

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

Advanced Materials, EarlyView.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song, Melissa Cadena, Myeongsoo Kim, Euisuk Chung, Jeungyoon Lee, Zlata Brushevich, Seonghun Shin, Paul S. Pelkowski, Stanislav Y. Emelianov   +8 more
wiley   +1 more source

The Paradox of Acute Myeloid Leukemia Responsiveness to Adoptive T-cell Therapy. [PDF]

Blood Cancer Discov
Fry TJ.
europepmc   +1 more source

In vivo nanoparticle-based T cell imaging can predict therapy response towards adoptive T cell therapy in experimental glioma. [PDF]

Theranostics, 2023
Hunger J, Schregel K, Boztepe B, Agardy DA, Turco V, Karimian-Jazi K, Weidenfeld I, Streibel Y, Fischer M, Sturm V, Santarella-Mellwig R, Kilian M, Jähne K, Sahm K, Wick W, Bunse L, Heiland S, Bunse T, Bendszus M, Platten M, Breckwoldt MO.   +20 more
europepmc   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source