Results 211 to 220 of about 57,324 (252)

Adoptive T cell cancer therapy

Nature Materials, 2018
Tumour heterogeneity and off-target toxicity are current challenges of cancer immunotherapy. Karine Dzhandzhugazyan, Per Guldberg and Alexei Kirkin discuss how epigenetic induction of tumour antigens in antigen-presenting cells may form the basis for multi-target therapies.
Karine N, Dzhandzhugazyan, Per, Guldberg, Alexei F, Kirkin   +2 more
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Prospects for adoptive T cell therapy

Current Opinion in Immunology, 1997
Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been identified and characterized for suitability as target antigens for immunotherapy. The development of innovative strategies to generate T cells targeting these antigens and lessons learned from clinical trials of ...
C, Yee, S R, Riddell, P D, Greenberg
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Principles of adoptive T cell therapy in cancer

Seminars in Immunopathology, 2018
Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells or T cells genetically engineered to express tumor recognizing receptors has emerged as a powerful and potentially curative therapy for several cancers.
Ozcan Met, Kasper Mølgaard, Inge Marie Svane   +2 more
exaly   +4 more sources

Adoptive T-Cell Therapy for Solid Malignancies

Surgical Oncology Clinics of North America, 2019
The use of immunotherapies for solid and hematologic malignancies has demonstrated durable antitumor effects. Use of checkpoint inhibitors allows for immunologic reactivation of the adaptive immune system against tumor-specific neoantigens and effective rejection.
Mohammad S, Jafferji, James C, Yang
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Adoptive T-Cell Therapy of Cancer

Hematology/Oncology Clinics of North America, 2006
Adoptive therapy involves the transfer of ex vivo expanded immune effector cells to patients as a means of augmenting the antitumor immune response. In general, this transfer is accomplished by harvesting cells from the peripheral blood, tumor sites, or draining lymph nodes and expanding effector cells in a specific or nonspecific fashion for adoptive ...
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Adoptive T-Cell Therapy in Sarcomas

Current Oncology Reports
To summarise and evaluate the latest adoptive T-cell therapies in sarcomas, focusing on therapeutic targets, efficacy, safety, and limitations.An increasing number of clinical trials are investigating adoptive T-cell therapies in sarcomas, most targeting NY-ESO-1 and MAGE-A4 through engineered T-cell receptors (TCR-T). The FDA approval of afamitresgene
Monika, Kucharczyk, Emine, Hatipoglu, Robin L, Jones, Paul H, Huang   +3 more
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Adoptive T-cell therapy.

Seminars in hematology, 1999
Adoptive immunotherapy, or the transfer of immunocompetent cells, has been shown to be a promising new strategy for treatment of a variety of malignancies, including leukemia and non-Hodgkin's lymphoma. The possibility that it may likewise benefit patients with multiple myeloma is now being explored by researchers in Europe and the United States.
Lokhorst, H.M., Liebowitz, D.
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Adoptive T cell therapy of solid cancers

Cancer Immunology, Immunotherapy, 2005
The development of immune-based approaches for the treatment of cancer has been actively investigated for many years. One strategy that has emerged as a potentially effective strategy for the treatment of aggressive established malignancies is adoptive T cell therapy. The power of this approach has been repeatedly observed in preclinical animal models.
Keith L, Knutson, Wolfgang, Wagner, Mary L, Disis   +2 more
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Neoantigen-Specific T Cells in Adoptive Cell Therapy

The Cancer Journal, 2022
Abstract The holy grail of cancer therapeutics is the destruction of cancer cells while avoiding harm to normal cells. Cancer is unique from normal tissues because of the presence of somatic mutations that accumulate during tumorigenesis.
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T Cell Receptors for Gene Transfer in Adoptive T Cell Therapy

Critical Reviews in Immunology, 2019
The past decade has seen enormous progress in cancer immunotherapy. Checkpoint inhibitors are a class of immunotherapy that act to recruit endogenous T cells of a patient's immune system against cancer-associated peptide- MHC antigens. In this process, mutated antigenic peptides referred to as neoantigens often serve as the target on cancer cells that ...
Preeti, Sharma, David M, Kranz
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