Results 31 to 40 of about 54,884 (249)
Harnessing Autophagy for Adoptive T-Cell Therapy [PDF]
Immunotherapy, 2011 Allogeneic hematopoietic cell transplantation (HCT), which is a treatment option for leukemia and lymphoma (reviewed in[1]), represents a form of adoptive T cell therapy (the graft-versus-tumor [GVT] effect). The majority of allogeneic transplants are performed using un-manipulated donor T cells, although as we will describe below, ex vivo manipulated ...
Shoba, Amarnath, Daniel H, Fowler
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Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation
Frontiers in Immunology, 2019 Delayed immune reconstitution and the consequently high rates of leukemia relapse and infectious complications are the main limitations of haploidentical hematopoietic stem cell transplantation.
Ping Zhang +3 more
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Adoptive B cell therapy for chronic viral infection
Frontiers in Immunology, 2022 T cell-based therapies have been widely explored for the treatment of cancer and chronic infection, but B cell-based therapies have remained largely unexplored.
Young Rock Chung +4 more
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European Journal of Case Reports in Internal MedicineIntroduction: Lung cancer is the second most common cancer worldwide and the leading cause of cancer deaths; non-small cell lung cancer (NSCLC) constitutes about 85% of lung cancer cases, with ALK fusions representing 3–6% of them.
Brenda Paola Rodriguez Arroyo +5 more
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Adoptive T-cell therapy for B-cell malignancies [PDF]
Expert Review of Hematology, 2009 The success of allogeneic hematopoietic cell transplantation (HCT) for B-cell malignancies is evidence that these tumors can be eliminated by T lymphocytes. This has encouraged the development of specific adoptive T-cell therapy, both for augmenting the anti-tumor effect of HCT and for patients not undergoing HCT.
Michael, Hudecek +3 more
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Adoptive T-Cell Therapy for Solid Tumors [PDF]
American Society of Clinical Oncology Educational Book, 2017 Chimeric antigen receptor (CAR) T-cell therapy is an innovative form of immunotherapy wherein autologous T cells are genetically modified to express chimeric receptors encoding an antigen-specific single-chain variable fragment and various costimulatory molecules. Upon administration, these modified T cells traffic to, and recognize, cancer cells in an
Oladapo, Yeku +2 more
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To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors
Frontiers in Immunology, 2020 The generation of immunological memory is a hallmark of adaptive immunity by which the immune system “remembers” a previous encounter with an antigen expressed by pathogens, tumors, or normal tissues; and, upon secondary encounters, mounts faster and ...
Anna Mondino, Teresa Manzo
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Regulation of Memory CD8+ T Cell Differentiation by MicroRNAs
Cellular Physiology and Biochemistry, 2018 MicroRNAs (miRNAs) have emerged as crucial regulators of T lymphocyte survival, differentiation and function, all of which are key factors impacting the outcome of adoptive T cell-based immunotherapy.
Zhen Zhang +4 more
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Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy
Cells, 2020 T cell receptor (TCR)-based adoptive T cell therapies (ACT) hold great promise for the treatment of cancer, as TCRs can cover a broad range of target antigens.
Jan A. Rath, Caroline Arber
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Chimeric Antigen Receptor T Cell Therapy in Hematology
Turkish Journal of Hematology, 2015 It is well demonstrated that the immune system can control and eliminate cancer cells. Immune-mediated elimination of tumor cells has been discovered and is the basis of both cancer vaccines and cellular therapies including hematopoietic stem cell ...
Pınar Ataca, Önder Arslan
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