Results 61 to 70 of about 3,239,660 (397)

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes [PDF]

, 1989
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings.
Jonjic, Stipan, Koszinowski, Ulrich H., Mutter, Wolfgang, Reddehase, Matthias J., Weiland, Frank   +4 more
core   +3 more sources

Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.

Blood, 2005
We previously demonstrated that autologous natural killer (NK)-cell therapy after hematopoietic cell transplantation (HCT) is safe but does not provide an antitumor effect.
Jeffrey S. Miller, Y. Soignier, A. Panoskaltsis‐Mortari, S. McNearney, Gong H Yun, S. Fautsch, D. McKenna, C. Le, T. Defor, L. Burns, P. Orchard, B. Blazar, J. Wagner, A. Slungaard, D. Weisdorf, I. Okazaki, P. Mcglave   +16 more
semanticscholar   +1 more source

Adoptive Cell Transfer in the Treatment of Metastatic Melanoma [PDF]

Journal of Investigative Dermatology, 2009
Adoptive cell therapy (ACT) for metastatic cancer is the focus of considerable research effort. Rosenberg's laboratory demonstrated a 50% response rate in stage IV melanoma patients treated with in vitro expanded tumor-infiltrating lymphocytes (TILs) and high-dose IL-2 administered after nonmyeloablative conditioning (Dudley et al., 2002a).
Straten, Per thor, Becker, Jürgen C
openaire   +4 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease [PDF]

, 2019
Soluble stimulation-2 (ST2) is increased during graft-versus-host disease (GVHD), while Tregs that express ST2 prevent GVHD through unknown mechanisms.
Blazar, Bruce R., Griesenauer, Brad, Hippen, Keli L., Liu, Hong, Loschi, Michael, Paczesny, Sophie, Ramadan, Abdulraouf, Reichenbach, Dawn K., Yang, Jinfeng, Zhang, Jilu   +9 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Tertiary lymphoid organs in central nervous system autoimmunity [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Mitsdoerffer, M., Peters, A.
core   +1 more source

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma.

Journal of Clinical Oncology, 2005
PURPOSE We investigated the combination of lymphodepleting chemotherapy followed by the adoptive transfer of autologous tumor reactive lymphocytes for the treatment of patients with refractory metastatic melanoma.
M. Dudley, J. Wunderlich, J. Yang, R. Sherry, S. Topalian, N. Restifo, R. Royal, U. Kammula, D. White, S. Mavroukakis, L. Rogers, Gerald J Gracia, S. Jones, David P. Mangiameli, M. M. Pelletier, J. Gea-Banacloche, M. Robinson, D. Berman, A. Filie, A. Abati, S. Rosenberg   +20 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model [PDF]

, 2015
B cells have been reported to promote graft rejection through alloantibody production. However, there is growing evidence that B cells can contribute to the maintenance of tolerance.
Alhabbab, R, Becker, PD, Blair, P, Elgueta, R, Howard, JK, Lechler, RI, Lombardi, G, Lord, GM, Marks, E, Noelle, RJ, O'Connell, S, Ratnasothy, K, Safinia, N, Sharif-Paghaleh, E, Smyth, L, Spencer, J, Stolarczyk, E   +16 more
core   +2 more sources