Results 131 to 140 of about 140,376 (246)
Cell Proliferation, EarlyView.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Similar to blood, saliva contains a broad range of biomarkers and may offer a non‐invasive, repeatable specimen for endocrine and metabolic assessment. This review aims to synthesise and evaluate recent advances in the clinical translation of salivary biomarkers, while providing a critical assessment of the diagnostic reliability and ...
Chuyan Yu +7 more
wiley +1 more source
ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites
, 2010 Poly(ADP-ribosyl)ation (PARylation) is involved in the maintaining of genomic methylation pattern through its control of DNA methyltranferase 1 (Dnmt1) activity.
REALE, Anna +8 more
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Journal of Integrative Plant Biology, EarlyView.This review covers recent progress in the understanding of stress‐responsive regulatory networks in soybean and highlights emerging genomic and breeding strategies. Integrating molecular insights and precision breeding will help to accelerate the development of climate‐resilient soybean cultivars.
Ali Shahzad +8 more
wiley +1 more source
Investigating differential binding of ADP-ribose by macrodomains [PDF]
, 2019 The post-translational modification ADP-ribosylation, whereby ADP-ribose subunits are attached to proteins to alter their function, has been previously implicated in processes including DNA damage repair and certain stress responses.
Hollingsworth, Derek Raymond
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Optimization of photobiomodulation therapy for spinal cord injury: A review
Photochemistry and Photobiology, EarlyView.Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew +3 more
wiley +1 more source
The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death
, 2011 The emergence of resistance to cancer treatments through methods that generate cell death by inducing DNA damage, such as chemotherapeutics and radiation therapy, is a major obstacle to overcoming the disease.
Finch, Kristin E.
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RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation
Photochemistry and Photobiology, EarlyView.UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan +3 more
wiley +1 more source