Results 91 to 100 of about 188,515 (292)
An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation.
Cell, 2020 Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are fundamental for creating the tools needed to explore this elusive post-translational modification (PTM) in essential cellular processes.
J. Bonfiglio +7 more
semanticscholar +1 more source
Coordinated actions of microRNAs with other epigenetic factors regulate skeletal muscle development and adaptation [PDF]
, 2017 Epigenetics plays a pivotal role in regulating gene expression in development, in response to cellular stress or in disease states, in virtually all cell types.
Adamo, Sergio +3 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation
eLife, 2016 PARP catalysed ADP-ribosylation is a post-translational modification involved in several physiological and pathological processes, including cellular stress.
Angelica Aguilera-Gomez +3 more
doaj +1 more source
The Critical Role of PARPs in Regulating Innate Immune Responses
Frontiers in Immunology, 2021 Poly (adenosine diphosphate-ribose) polymerases (PARPs) are a family of proteins responsible for transferring ADP-ribose groups to target proteins to initiate the ADP-ribosylation, a highly conserved and fundamental post-translational modification in all
Huifang Zhu +4 more
doaj +1 more source
Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]
, 2015 Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core
The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]
, 2015 The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika +2 more
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Mapping Physiological ADP-Ribosylation Using Activated Ion Electron Transfer Dissociation
bioRxiv, 2020 ADP-ribosylation (ADPr) is a post-translational modification that plays pivotal roles in a wide range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under physiological conditions, without relying on genetic or chemical perturbation,
Sara C. Buch-Larsen +8 more
semanticscholar +1 more source
TARG1 protects against toxic DNA ADP-ribosylation
Nucleic Acids Research, 2021 ADP-ribosylation is a modification that targets a variety of macromolecules and regulates a diverse array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases and reversed by ADP-ribosylhydrolases.
Callum Tromans-Coia +5 more
semanticscholar +1 more source