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ADP Ribosylation [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Ayurvedic Phytochemicals in Oncology: ADP-Ribosylation as a Molecular Nexus. [PDF]

Cells
Reddy GSVSR, Nandy SK, Cherukuri P, Samanta K, Kar P.   +4 more
europepmc   +3 more sources

General ADP-Ribosylation Mechanism Based on the Structure of ADP-Ribosyltransferase–Substrate Complexes [PDF]

Toxins
ADP-ribosylation is a ubiquitous modification of proteins and other targets, such as nucleic acids, that regulates various cellular functions in all kingdoms of life.
Hideaki Tsuge, Noriyuki Habuka, Toru Yoshida   +2 more
doaj   +2 more sources

ADP-Ribosylation in Antiviral Innate Immune Response

Pathogens, 2023
Adenosine diphosphate (ADP)-ribosylation is a reversible post-translational modification catalyzed by ADP-ribosyltransferases (ARTs). ARTs transfer one or more ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to the target substrate and release ...
Qian Du, Ying Miao, Wei He, Hui Zheng
doaj   +1 more source

Functional roles of ADP-ribosylation writers, readers and erasers

Frontiers in Cell and Developmental Biology, 2022
ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers.
Ping Li, Yushuang Lei, Jia Qi, Wanqin Liu, Kai Yao   +4 more
doaj   +1 more source

ADP-ribosylation from molecular mechanisms to therapeutic implications

Cell, 2023
Summary ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life.
M. Suskiewicz, Evgeniia A. Prokhorova, J. Rack, I. Ahel   +3 more
semanticscholar   +1 more source

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

bioRxiv, 2022
Plant pathogen-activated immune signaling by nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/Interleukin-1 receptor (TIR) domain converges on Enhanced Disease Susceptibility 1 (EDS1) and its direct partners Phytoalexin ...
Ao Jia, Shijia Huang, Wen Song, Junli Wang, Yonggang Meng, Yue Sun, Lina Xu, Henriette Laessle, J. Jirschitzka, Jiao Hou, Tiantian Zhang, Wenquan Yu, Giuliana Hessler, Ertong Li, Shoucai Ma, Dongli Yu, J. Gebauer, U. Baumann, Xiaohui Liu, Zhifu Han, Junbiao Chang, J. Parker, J. Chai   +22 more
semanticscholar   +1 more source

Characterization of an Aedes ADP-Ribosylation Protein Domain and Role of Post-Translational Modification during Chikungunya Virus Infection

Pathogens, 2023
Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar, Divya Mehta, Debasis Nayak, Sujatha Sunil   +3 more
doaj   +1 more source

Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

Molecules and Cells, 2023
Summary PARP1, an established anti-cancer target that regulates many cellular pathways, including DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)transferase. Although recent studies have revealed the prevalence of mono-
E. Longarini, Helen Dauben, C. Locatelli, Anne R. Wondisford, Rebecca Smith, Charlotte Muench, Andreas Kolvenbach, M. L. Lynskey, A. Pope, J. Bonfiglio, Eva Pinto Jurado, R. Fajka‐Boja, T. Colby, M. Schuller, I. Ahel, Gyula Timinszky, Roderick J. O’Sullivan, S. Huet, I. Matic   +18 more
semanticscholar   +1 more source

PARPs and ADP-ribosylation: Deciphering the complexity with molecular tools.

Molecules and Cells, 2023
PARPs catalyze ADP-ribosylation-a post-translational modification that plays crucial roles in biological processes, including DNA repair, transcription, immune regulation, and condensate formation.
Morgan Dasovich, A. Leung
semanticscholar   +1 more source