Results 61 to 70 of about 188,515 (292)
Nature Communications, 2022 Serum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels.
Megha Jhanji +10 more
semanticscholar +1 more source
The role of ADP-ribosylation in regulating DNA interstrand crosslink repair [PDF]
, 2016 ADP-ribosylation by ADP-ribosyltransferases (ARTs) has a wellestablished role in DNA strand break repair by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium
Ahel, Ivan +10 more
core +4 more sources
Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress [PDF]
, 2013 Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA.
Argüelles-Castilla, Sandro +5 more
core +1 more source
Beyond protein modification: the rise of non-canonical ADP-ribosylation
Biochemical Journal, 2022 ADP-ribosylation has primarily been known as post-translational modification of proteins. As signalling strategy conserved in all domains of life, it modulates substrate activity, localisation, stability or interactions, thereby regulating a variety of ...
M. Schuller, I. Ahel
semanticscholar +1 more source
Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core +1 more source
Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation
Molecules and Cells, 2021 Summary In addition to its role as an electron transporter, mitochondrial nicotinamide adenine dinucleotide (NAD+) is an important co-factor for enzymatic reactions, including ADP-ribosylation.
Ann-Katrin Hopp +12 more
semanticscholar +1 more source
Roles of ADP-Ribosylation during Infection Establishment by Trypanosomatidae Parasites
Pathogens, 2023 ADP-ribosylation is a reversible post-translational protein modification, which is evolutionarily conserved in prokaryotic and eukaryotic organisms.
Joshua Dowling, Craig L. Doig
doaj +1 more source
Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.
Cell, 2021 Defects in translation lead to changes in the expression of proteins that can serve as drivers of cancer formation. Here, we show that cytosolic NAD+ synthesis plays an essential role in ovarian cancer by regulating translation and maintaining protein ...
S. Challa +8 more
semanticscholar +1 more source
Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions [PDF]
, 2013 Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by the fact that eEF2 is sensitive to
Argüelles Castilla, Sandro +3 more
core +1 more source
Cells, 2021 ADP-ribosylation is a post-translational protein modification catalyzed by a family of proteins known as poly-ADP-ribose polymerases. PARP7 (TIPARP; ARTD14) is a mono-ADP-ribosyltransferase involved in several cellular processes, including responses to ...
Marit Rasmussen +8 more
semanticscholar +1 more source