Results 1 to 10 of about 32,710,223 (183)

Interplay of Histone Marks with Serine ADP-Ribosylation [PDF]

Cell Reports, 2018
Summary: Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1).
Juan José Bonfiglio, Evgeniia Prokhorova, Ivan Ahel   +2 more
exaly   +4 more sources

Nanoparticles (PLGA and Chitosan)-Entrapped ADP-Ribosylation Factor 1 of Haemonchus contortus Enhances the Immune Responses in ICR Mice [PDF]

Vaccines, 2020
ADP-ribosylation factor 1 (HcARF1) is one of the Haemonchus contortus (H. contortus) excretory/secretory proteins involved in modulating the immune response of goat peripheral blood mononuclear cells (PBMC).
Muhammad Waqqas Hasan, Muhammad Haseeb, Muhammad Ehsan, Javaid Ali Gadahi, Muhammad Ali-ul-Husnain Naqvi, Qiang Qiang Wang, Xinchao Liu, Shakeel Ahmed Lakho, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li   +11 more
doaj   +2 more sources

Partial Protection of Goats against Haemonchus contortus Achieved with ADP-Ribosylation Factor 1 Encapsulated in PLGA Nanoparticles [PDF]

Vaccines
Background: Haemonchus contortus (H. contortus), a nematode with global prevalence, poses a major threat to the gastrointestinal health of sheep and goats.
Muhammad Waqqas Hasan, Javaid Ali Gadahi, Muhammad Haseeb, Qiangqiang Wang, Muhammad Ehsan, Shakeel Ahmad Lakho, Ali Haider, Tahir Aleem, Mingmin Lu, Ruofeng Yan, Xiaokai Song, Xiangrui Li, Lixin Xu   +12 more
doaj   +2 more sources

ADP-ribosylation: An emerging regulator of the epigenome. [PDF]

Mol Oncol
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Camacho CV, Liu C, Kraus WL.
europepmc   +2 more sources

NAD⁺ Metabolism Licenses Zygotic Genome Activation via PARP7-Mediated ADP-Ribosylation of UHRF1 in Mouse Early Embryos. [PDF]

Adv Sci (Weinh)
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Cao G, Zhang Z, Chen A, Liu Y, Lin Y, Yu L, Shi R, Guo A, Mao Y, Lou G, Li C, Wen L, Yan G, Sun H.   +13 more
europepmc   +2 more sources

The Potential Target Value of ADP-Ribosylation Factor 6 in Insulin Secretion Regulation and the Treatment of Metabolic Disorders [PDF]

Metabolites
Obesity and type 2 diabetes mellitus (T2DM) represent pandemic metabolic illnesses hallmarked by defective pancreatic β-cell function and blunted insulin release.
Yangyang Wang
doaj   +2 more sources

The interplay of TARG1 and PARG protects against genomic instability

Cell Reports, 2023
Summary: The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the physiological role of TARG1, an ADP-ribosylhydrolase that removes aspartate/
Joséphine Groslambert, Evgeniia Prokhorova, Anne R. Wondisford, Callum Tromans-Coia, Celeste Giansanti, Jennifer Jansen, Gyula Timinszky, Matthias Dobbelstein, Dragana Ahel, Roderick J. O’Sullivan, Ivan Ahel   +10 more
doaj   +1 more source

Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. [PDF]

PLoS ONE, 2014
Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation.
Markus Dahl, Varun Maturi, Peter Lönn, Panagiotis Papoutsoglou, Agata Zieba, Michael Vanlandewijck, Lars P van der Heide, Yukihide Watanabe, Ola Söderberg, Michael O Hottiger, Carl-Henrik Heldin, Aristidis Moustakas   +11 more
doaj   +1 more source

C9orf72 Toxic Species Affect ArfGAP-1 Function

Cells, 2023
Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in C9orf72, the most common cause of genetic ALS, have
Simona Rossi, Michela Di Salvio, Marilisa Balì, Assia De Simone, Savina Apolloni, Nadia D’Ambrosi, Ivan Arisi, Francesca Cipressa, Mauro Cozzolino, Gianluca Cestra   +9 more
doaj   +1 more source

ARH Family of ADP-Ribose-Acceptor Hydrolases

Cells, 2022
The ARH family of ADP-ribose-acceptor hydrolases consists of three 39-kDa members (ARH1-3), with similarities in amino acid sequence. ARH1 was identified based on its ability to cleave ADP-ribosyl-arginine synthesized by cholera toxin.
Hiroko Ishiwata-Endo, Jiro Kato, Sachiko Yamashita, Chanbora Chea, Kazushige Koike, Duck-Yeon Lee, Joel Moss   +6 more
doaj   +1 more source