Results 31 to 40 of about 32,710,223 (183)

CD13 regulation of membrane recycling: implications for cancer dissemination

Molecular & Cellular Oncology, 2019
Membrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif ...
Mallika Ghosh, Linda H. Shapiro
doaj   +1 more source

ADP-Ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS Toxin Regulates Inflammasome Activity

mBio, 2014
The inflammasome is a major regulator of inflammation through its activation of procaspase-1, which cleaves prointerleukin-1β (pro-IL-1β) into its mature form.
Santanu Bose, Jesus A. Segovia, Sudha R. Somarajan, Te-Hung Chang, T. R. Kannan, Joel B. Baseman   +5 more
doaj   +1 more source

Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1

Nature Communications, 2023
ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and membranes to regulate intracellular traffic, organelle structure and actin dynamics.
Yue Zhang, Olivier Soubias, Shashank Pant, Frank Heinrich, Alexander Vogel, Jess Li, Yifei Li, Luke A. Clifton, Sebastian Daum, Kirsten Bacia, Daniel Huster, Paul A. Randazzo, Mathias Lösche, Emad Tajkhorshid, R. Andrew Byrd   +14 more
doaj   +1 more source

Poly(ADP)ribosylation of nuclear proteins in the mouse testis

, 1984
In "Proceedings of the 7th Intern. Symp.
R.,. JONES, QUESADA, PIERINA MARIA, M. MALANGA R. JONES, Enzo Leone, M. MALANGA AND R. JONES, LEONE E, JONES R., E. LEONE, Piera Quesada, Roy Jones, FARINA, BENEDETTA, B. , FARINA, Benedetta Farina, P. QUESADA, B. FARINA, FARINA B, M. , MALANGA, Maria R. Faraone Mennella, E. , LEONE, P. , QUESADA, Maria Malanga, FARAONE MENNELLA, MARIA ROSARIA, MALANGA M   +22 more
core   +1 more source

Plasmodium yoelii: identification of a gene encoding a putative ADP-ribosylation factor-1 GTPase-activating Protein, PyAG1

Memorias do Instituto Oswaldo Cruz, 2000
The PyAG1 gene, identified by the screening of a Plasmodium yoelii genomic DNA library with a rhoptry-specific Mab, encodes a protein with a zinc finger structure immediately followed by the consensus sequence of the Arf GAP catalytic site.
Rémi Hienne, Alain Rico, Daniel Parzy, Jean-Claude Doury   +3 more
doaj   +1 more source

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Journal of Inflammation, 2011
Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine ...
Zingarelli Basilia, Gefter Julia V, Sjodin Hanna, Aneja Rajesh K, Delude Russell L   +4 more
doaj   +1 more source

Role of ADP ribosylation factor guanylate kinase 1 in the malignant biological behavior of gastric cancer

Heliyon
Aim: This study aims to investigate the influence of ASAP1 (ADP ribosylation factor guanylate kinase 1) on the malignant behavior of gastric cancer (GC) cells and to elucidate the potential molecular mechanisms involved in cancer development and ...
Qiong Luo, Suyun Zhang, Fan Yang, Rui Feng, Qian Xu, Xiangqi Chen, Sheng Yang   +6 more
doaj   +1 more source

ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.

PLoS ONE, 2012
Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors, the P2Y(1) and P2Y(12) purinoceptors. Recently, we demonstrated that P2Y(1) and P2Y(12) purinoceptor activities are
Venkateswarlu Kanamarlapudi, Sian E Owens, Keya Saha, Robert J Pope, Stuart J Mundell   +4 more
doaj   +1 more source

TARG1 protects against DNA ADP-ribosylation stress [PDF]

, 2021
ADP-ribosylation is a modification that can target a variety of macromolecules and can regulate an array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases that use NAD+ as a cosubstrate to transfer ADP-ribose onto ...
Tromans-Coia, Callum
core   +1 more source

Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells

Translational Oncology
The preference of cancer cells to generate energy from glycolysis for rapid cell proliferation is called the Warburg effect. Poly(ADP-ribose) polymerase 1 (PARP1) performs various cellular functions, including poly-ADP-ribosylation and DNA repair. In the
Chenxuan Zhang, Peng Wang, Jia Yu, Jianhui Yuan, Lilong Zhang, Man Li   +5 more
doaj   +1 more source