Results 101 to 110 of about 213,935 (349)

Coordination of IFT20 With Other IFT Components Is Required for Ciliogenesis

Journal of Clinical Laboratory Analysis, EarlyView.
Intraflagellar transport is a bidirectional transport system essential for ciliogenesis. Using the IFT20 knockout cell lines established in this study, we found that IFT20 deficiency significantly impaired ciliogenesis and reduced cilium length. Further investigation revealed that IFT20 interacted with other IFT proteins and regulated their levels and ...
Weishu Wang, Ying Shan, Ruming Liu, Dengwen Li, Jun Zhou, Quanlong Lu, Huijie Zhao   +6 more
wiley   +1 more source

Clostridial binary toxins: iota and C2 family portraits

Frontiers in Cellular and Infection Microbiology, 2011
There are many pathogenic Clostridium species with diverse virulence factors that include protein toxins. Some of these bacteria, such as C. botulinum, C. difficile, C. perfringens and C. spiroforme, cause enteric problems in animals as well as humans.
Bradley G. Stiles, Darran J. Wigelsworth, Michel R. Popoff, Holger eBarth   +3 more
doaj   +1 more source

Risk factor aggregation and stress testing [PDF]

arXiv, 2023
Stress testing refers to the application of adverse financial or macroeconomic scenarios to a portfolio. For this purpose, financial or macroeconomic risk factors are linked with asset returns, typically via a factor model. We expand the range of risk factors by adapting dimension-reduction techniques from unsupervised learning, namely PCA and ...
arxiv  

Localization and Characterization of the Human ADP-Ribosylation Factor 5 (ARF5) Gene [PDF]

Genomics, 1997
ADP-ribosylation factor 5 (ARF5) is a member of the ARF gene family. The ARF proteins stimulate the in vitro ADP-ribosyltransferase activity of cholera toxin and appear to play a role in vesicular trafficking in vivo. We have mapped ARF5, one of the six known mammalian ARF genes, to a well-defined yeast artificial chromosome contig on human chromosome ...
McGuire, Rachel E., Daiger, Stephen P., Green, Eric D.   +2 more
openaire   +4 more sources

Comparative Proteomics of Salinity Stress Responses in Fish and Aquatic Invertebrates

PROTEOMICS, EarlyView.
ABSTRACT Fluctuating salinity is symptomatic of climate change challenging aquatic species. The melting of polar ice, rising sea levels, coastal surface and groundwater salinization, and increased evaporation in arid habitats alter salinity worldwide. Moreover, the frequency and intensity of extreme weather events such as rainstorms and floods increase,
Maxime Leprêtre, Jens Hamar, Monica B. Urias, Dietmar Kültz   +3 more
wiley   +1 more source

NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair

Cell Reports, 2019
Summary: Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood.
Deeksha Munnur, Joanna Somers, George Skalka, Ria Weston, Rebekah Jukes-Jones, Mohammed Bhogadia, Cyril Dominguez, Kelvin Cain, Ivan Ahel, Michal Malewicz   +9 more
doaj  

Transcriptional regulation mechanism of PARP1 and its application in disease treatment

Epigenetics & Chromatin
Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryotic cells. In addition to maintaining genomic integrity, this nuclear enzyme is also involved in transcriptional regulation.
Yu Lu, Wenliang Fu, Weiwei Xing, Haowei Wu, Chao Zhang, Donggang Xu   +5 more
doaj   +1 more source

On Factor Left Prime Factorization Problems for Multivariate Polynomial Matrices [PDF]

arXiv, 2020
This paper is concerned with factor left prime factorization problems for multivariate polynomial matrices without full row rank. We propose a necessary and sufficient condition for the existence of factor left prime factorizations of a class of multivariate polynomial matrices, and then design an algorithm to compute all factor left prime ...
arxiv  

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +3 more sources

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source