PLoS PathogensThe host interferon pathway upregulates intrinsic restriction factors in response to viral infection. Many of them block a diverse range of viruses, suggesting that their antiviral functions might have been shaped by multiple viral families during ...
Serina Huang +6 more
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Cell ReportsSummary: Here, we show that conventional human pluripotent stem cells cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells (
Ludovic Zimmerlin +11 more
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Frontiers in MicrobiologySARS-CoV-2 reprograms host cell biology not solely through its genomic content but also through a sophisticated arsenal of post-translational modifications (PTMs) that modulate viral protein function, host signaling networks, and immune responses ...
Jie Qu, Minglong Liu, Chen Zhou
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Zebrafish arl6ip1 is required for neural crest development during embryogenesis.
PLoS ONE, 2012 BackgroundAlthough the embryonic expression pattern of ADP ribosylation factor-like 6 interacting protein 1 (Arl6ip1) has been reported, its function in neural crest development is unclear.Methods/principal findingsWe found that knockdown of Arl6ip1 ...
Chi-Tang Tu +3 more
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Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]
, 2019 The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
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Caracterização funcional dos genes codificadores de proteínas ADP-Ribosylation Factor no fungo filamentoso patogênico Aspergillus fumigatus [PDF]
, 2017 Mário Henrique Paziani
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The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair [PDF]
, 2018 Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A.
Baranes Bachar, Keren +4 more
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A role for ADP‐ribosylation factor 1, but not COP I, in secretory vesicle biogenesis from the trans‐Golgi network [PDF]
, 1996 Francis A. Barr, Wieland Β. Huttner
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The importance of Poly(ADP-Ribose) Polymerase as a sensor of unligated Okazaki fragments during DNA replication [PDF]
, 2018 Poly(ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA breaks. Surprisingly, however, we show that most if not all endogenous poly(ADP-ribose) is detected in normal S phase cells at sites of DNA replication. This S phase poly(
Caldecott, Keith W +5 more
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Golgi-localizing, γ-Adaptin Ear Homology Domain, ADP-ribosylation Factor-binding (GGA) Proteins Interact with Acidic Dileucine Sequences within the Cytoplasmic Domains of Sorting Receptors through Their Vps27p/Hrs/STAM (VHS) Domains [PDF]
, 2001 Hiroyuki Takatsu +3 more
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