Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, EarlyView., 2023 Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
The role of ADP-ribosylation in regulating DNA interstrand crosslink repair [PDF]
, 2016 ADP-ribosylation by ADP-ribosyltransferases (ARTs) has a wellestablished role in DNA strand break repair by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium
Ahel, Ivan +10 more
core +4 more sources
ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion
Molecular & Cellular Oncology, 2020 Endocytic trafficking has emerged as an essential mechanism to spatiotemporally coordinate signaling protein complexes that control cytoskeletal dynamics and cell motility. Our study established an unexpected regulatory mechanism whereby ADP ribosylation
Kossay Zaoui +3 more
doaj +1 more source
EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor
Cells, 2021 Axon regeneration after injury is a conserved biological process that involves a large number of molecular pathways, including rapid calcium influx at injury sites, retrograde injury signaling, epigenetic transition, transcriptional reprogramming ...
Gilberto Gonzalez, Lizhen Chen
doaj +1 more source
Expression of ADP-ribosylation enzymes in mouse embryos and muscle cell cultures [PDF]
, 2006 Skeletal muscle myogenesis is a highly regulated process involving distinct changes in activation of transcription factors and gene expression driven by these transcription factors.
Brooks, Benjamin David
core +5 more sources
Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic.
Molecular Biology of the Cell, 2005 The ADP-ribosylation factors (Arfs) are six proteins within the larger Arf family and Ras superfamily that regulate membrane traffic. Arfs all share numerous biochemical activities and have very similar specific activities.
L. Volpicelli-Daley +3 more
semanticscholar +1 more source
PARP inhibitor resistance: the underlying mechanisms and clinical implications
Molecular Cancer, 2020 Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi targeting poly (ADP-ribose) polymerase (PARP) have been approved for ovarian
He Li +5 more
doaj +1 more source
Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions [PDF]
, 2013 Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by the fact that eEF2 is sensitive to
Argüelles Castilla, Sandro +3 more
core +1 more source
Characterization of ERp29 and ADP-Ribosylation Factor 5 Interaction [PDF]
Journal of Life Science, 2011 ERp29 is a endoplasmic reticulum (ER) lumenal resident protein that shows sequence similarity to the protein disulfide isomerase family. Its biological function is thought to play a role in the processing of secretory proteins within the ER, possibly by participating in the folding of proteins in the ER.
Kweon Yu +4 more
openaire +2 more sources
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
Frontiers in Microbiology, 2021 Clostridioides difficile is a major cause of nosocomial infection worldwide causing antibiotic-associated diarrhea and some cases are leading to pseudomembranous colitis. The main virulence factors are toxin A and toxin B.
Florian Stieglitz +4 more
doaj +1 more source