PARP inhibitor resistance: the underlying mechanisms and clinical implications
Molecular Cancer, 2020 Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi targeting poly (ADP-ribose) polymerase (PARP) have been approved for ovarian
He Li +5 more
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Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions [PDF]
, 2013 Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by the fact that eEF2 is sensitive to
Argüelles Castilla, Sandro +3 more
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Characterization of ERp29 and ADP-Ribosylation Factor 5 Interaction [PDF]
Journal of Life Science, 2011 ERp29 is a endoplasmic reticulum (ER) lumenal resident protein that shows sequence similarity to the protein disulfide isomerase family. Its biological function is thought to play a role in the processing of secretory proteins within the ER, possibly by participating in the folding of proteins in the ER.
Kweon Yu +4 more
openaire +2 more sources
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
Frontiers in Microbiology, 2021 Clostridioides difficile is a major cause of nosocomial infection worldwide causing antibiotic-associated diarrhea and some cases are leading to pseudomembranous colitis. The main virulence factors are toxin A and toxin B.
Florian Stieglitz +4 more
doaj +1 more source
Cellular Microbiology, 2016 GBF1 is a host factor required for hepatitis C virus (HCV) replication. GBF1 functions as a guanine nucleotide exchange factor for G‐proteins of the Arf family, which regulate membrane dynamics in the early secretory pathway and the metabolism of ...
Rayan Farhat +8 more
semanticscholar +1 more source
Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress [PDF]
, 2013 Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA.
Argüelles-Castilla, Sandro +5 more
core +1 more source
Key molecules of Mucorales for COVID-19-associated mucormycosis: a narrative review
Journal of Bio-X Research, 2022 Mucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales.
Priyanka Baberwal +3 more
doaj +1 more source
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
ADP‐ribosylated elongation factor 2 (ADP‐ribosyl‐EF‐2) is unable to promote translocation within the ribosome [PDF]
FEBS Letters, 1990 Elongation factor 2 (EF‐2), ADP‐ribosylated in vitro by the A‐fragment of diphtheria toxin, can (in the presence of GMPPCP) form stable corn plexes with ribosomes regardless of whether the ribosomes are empty or carrying poly(U) and Phe‐tRNA in the A‐site.
E.K. Davydova, Lev P. Ovchinnikov
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Toxins, 2020 Pathogenic microorganisms produce various virulence factors, e.g., enzymes, cytotoxins, effectors, which trigger development of pathologies in infectious diseases. Cholera toxin (CT) produced by O1 and O139 serotypes of Vibrio cholerae (V. cholerae) is a
Kohei Ogura, Kinnosuke Yahiro, Joel Moss
doaj +1 more source