Results 61 to 70 of about 46,883 (258)

Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies and replication of grass carp reovirus

Frontiers in Immunology, 2022
Grass carp reovirus (GCRV) is the most pathogenic double-stranded (ds) RNA virus among the isolated aquareoviruses. The molecular mechanisms by which GCRV utilizes host factors to generate its infectious compartments beneficial for viral replication and ...
Jie Zhang, Pengwei Li, Pengwei Li, Riye Lu, Songying Ouyang, Ming Xian Chang, Ming Xian Chang, Ming Xian Chang   +7 more
doaj   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Clinical implication and immunological characterisation of the ARF-GEF family member CYTH4 in ovarian cancer

Autoimmunity, 2020
Background The GTP exchange factors on ADP-ribosylation factor (ARF) mediate the GDP/GTP exchange on ARF, serve as regulators in protein trafficking and membrane dynamics, and play critical roles in various cell processes.
Qinyi Zhang, Qingying Wang, Sufang Wu, Jiawen Zhang   +3 more
doaj   +1 more source

Inhibition of Cell Migration by PITENINs: The Role of ARF6 [PDF]

, 2012
We have previously reported the development of small molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and show anti-tumor potential.
Degterev, Alexei, Famulok, Michael, Fu, Xueyan, Miao, Benchun, Schaffhausen, Brian, Skidan, Igor, Torchilin, Vladimir, Yang, Jinsheng, You, Zerong, Yuan, Junying   +9 more
core   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

The leishmania ARL-1 and Golgi traffic. [PDF]

PLoS ONE, 2008
We present here the characterisation of the Leishmania small G protein ADP-Ribosylation Factor-Like protein 1 (ARL-1). The ARL-1 gene is present in one copy per haploid genome and conserved among trypanosomatids.
Annelise Sahin, Benoît Espiau, Emmanuel Tetaud, Armelle Cuvillier, Lydia Lartigue, Audrey Ambit, Derrick R Robinson, Gilles Merlin   +7 more
doaj   +1 more source

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor, Boyett, Marc, Dobrzynski, Halina, Dézsi, László, Erdélyi, Lajos, Papp, Gyula, Szalontai, Balázs, Szüts, Viktória, Varró, András, Vágvölgyi, Csaba, Zhang, Henggui, Ötvös, Ferenc   +11 more
core  

Organelle Sorting and Proteomic Analysis to Identify Proteins Involved in the Uptake and Intracellular Trafficking of Nanoparticles

Small Methods, EarlyView.
A new method to identify proteins involved in the uptake and intracellular trafficking of nanoparticles is presented. After nanoparticle uptake, cells are lysed and the organelles with nanoparticles are purified using fluorescence assisted cell sorting. Next, their composition is determined by proteomic analysis.
Hector Garcia Romeu, Anna Salvati
wiley   +1 more source

Transcriptional regulation mechanism of PARP1 and its application in disease treatment

Epigenetics & Chromatin
Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryotic cells. In addition to maintaining genomic integrity, this nuclear enzyme is also involved in transcriptional regulation.
Yu Lu, Wenliang Fu, Weiwei Xing, Haowei Wu, Chao Zhang, Donggang Xu   +5 more
doaj   +1 more source

Critical assessment of microscopy methods for detecting single- and double-strand DNA breaks

Folia Histochemica et Cytobiologica
A laboratory toolbox for detecting and quantifying DNA breaks in animal cells and tissues includes various methods that employ biochemical tests, DNA sequencing, or imaging approaches.
Agnieszka Hoang-Bujnowicz, Julita Wesolowska, Agnieszka Ostromecka, Beata Nosal, Weronika Pawlus, Svitlana Levchenko, Miroslaw Zarebski, Jurek W. Dobrucki   +7 more
doaj   +1 more source