Results 71 to 80 of about 45,518 (211)

STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic Inflammation [PDF]

, 2016
Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the ...
Kaplan, Mark H., Krishnamurthy, Purna
core   +1 more source

Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer

Cellular and Molecular Life Sciences
Poly(ADP-ribose)polymerase 2 (PARP2) is a nuclear protein, DNA damage sensor and an emerging target for development of anti-cancer drugs. Previously it was discovered that PARP2 binds to nucleosomes; however, critical factors involved in this process ...
Natalya Maluchenko, Alexandra Saulina, Olga Geraskina, Elena Kotova, Anna Korovina, Grigoriy Armeev, Mikhail Kirpichnikov, Alexey Feofanov, Vasily Studitsky   +8 more
doaj   +1 more source

Analyzing the safety of the parasiticide fungus Mucor circinelloides: first insights on its virulence profile and interactions with the avian gut microbial community

Microbiology Spectrum
Parasiticide fungi are considered an accurate, sustainable, and safe solution for the biocontrol of animal gastrointestinal (GI) parasites. This research provides an initial characterization of the virulence of the native parasiticide fungus Mucor ...
João Lozano, Eva Cunha, Cristina Almeida, Mónica Nunes, Ricardo Dias, Eduardo Vicente, Daniela Sebastião, Sérgio Henriques, Luís Madeira de Carvalho, Adolfo Paz-Silva, Manuela Oliveira   +10 more
doaj   +1 more source

Characterization of shikonin derivative secretion in Lithospermum eryrhirorizon hairy roots as a model of lipid-soluble metabolite secretion from plants.

Frontiers in Plant Science, 2016
Shikonin derivatives are specialized lipophilic metabolites, secreted in abundant amounts from the root epidermal cells of Lithospermum erythrorhizon.
Kanade Tatsumi, Mariko Yano, Kenta Kaminade, Akifumi Sugiyama, Mayuko Sato, Kiminori Toyooka, Takashi Aoyama, Fumihiko Sato, Kazufumi Yazaki   +8 more
doaj   +1 more source

Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: Regulation by phosphoinositides and ADP-Ribosylation Factors

Biological Research, 2002
The ADP-ribosylation factor family of small GTP-binding proteins are implicated in the regulation of vesicular transport and control of cytoskeletal and cell adhesion events.
MUHAMED A. HAWADLE, NAJEEM FOLARIN, ROSEMARY MARTIN, TREVOR R. JACKSON   +3 more
doaj  

ARTD2 activity is stimulated by RNA [PDF]

, 2017
ADP-ribosyltransferases (ARTs) are important enzymes that regulate the genotoxic stress response and the maintenance of genome integrity. ARTD1 (PARP1) and ARTD2 (PARP2) are homologous proteins that modify themselves and target proteins by the addition ...
Bär, Dominik, Hottiger, Michael O., Léger, Karolin, Santoro, Raffaella, Savić, Nataša   +4 more
core  

Poly(ADP-ribose) Polymerase-1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Potential [PDF]

, 2014
Poly(ADP-ribosyl)ation reactions, carried out by poly(ADP-ribose) polymerases (PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous cellular processes (e.g., DNA repair, transcription, metabolism, or immune functions). PARP1
Bay, Péter, Little, P., Liu, P., Xu, S.
core   +1 more source

Positive selection analyses identify a single WWE domain residue that shapes ZAP into a more potent restriction factor against alphaviruses.

PLoS Pathogens
The host interferon pathway upregulates intrinsic restriction factors in response to viral infection. Many of them block a diverse range of viruses, suggesting that their antiviral functions might have been shaped by multiple viral families during ...
Serina Huang, Juliana Girdner, LeAnn P Nguyen, Carina Sandoval, Oliver I Fregoso, David Enard, Melody M H Li   +6 more
doaj   +1 more source

Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis

Cell Reports
Summary: Here, we show that conventional human pluripotent stem cells cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells (
Ludovic Zimmerlin, Ariana Angarita, Tea Soon Park, Rebecca Evans-Moses, Justin Thomas, Sirui Yan, Isabel Uribe, Isabella Vegas, Clara Kochendoerfer, Willem Buys, Anthony K.L. Leung, Elias T. Zambidis   +11 more
doaj   +1 more source

Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture [PDF]

, 2019
Background: Filamentous fungal cell factories are used to produce numerous proteins, enzymes, and organic acids. Protein secretion and filamentous growth are tightly coupled at the hyphal tip. Additionally, both these processes require ATP and amino acid
Cairns, Timothy C., Feurstein, Claudia, Meyer, Vera, Sun, Jibin, Zhang, Li Hui, Zheng, Ping, Zheng, Xiaomei   +6 more
core   +1 more source