Results 81 to 90 of about 213,935 (349)

Disruption of macrodomain protein SCO6735 increases antibiotic production in Streptomyces coelicolor [PDF]

, 2016
ADP-ribosylation is a post-translational modification that can alter the physical and chemical properties of target proteins and controls many important cellular processes. Macrodomains are evolutionarily conserved structural domains that bind ADP-ribose
Ahel, Ivan, Ahel, Marijan, Bucca, Giselda, Colby, Thomas, Halasz, Mirna, Jankevicius, Gytis, Lalić, Jasna, Luić, Marija, Matić, Ivan, Mikoč, Andreja, Palazzo, Luca, Perina, Dragutin, Pleše, Bruna, Posavec Marjanović, Melanija, Sabljić, Igor, Ćetković, Helena, Žaja, Roko   +16 more
core   +1 more source

Binding and Functions of ADP-ribosylation Factor on Mammalian and Yeast Peroxisomes [PDF]

Journal of Biological Chemistry, 2005
We have analyzed in vitro the binding characteristics of members of the ADP-ribosylation factor (ARF) family of proteins to a highly purified rat liver peroxisome preparation void of Golgi membranes and studied in vivo a role these proteins play in the proliferation of yeast peroxisomes.
Bianka L. Grosshans, Dorothee Lay, Hans Heid, Wilhelm W. Just, Karin Gorgas   +4 more
openaire   +3 more sources

Noncoding RNAs in Host–Microbiota Interaction

Animal Research and One Health, EarlyView.
The intricate interplay between gut microbiota and the host exerts a profound impact on host biological processes and disease development. This review highlights the pivotal role of noncoding RNAs (ncRNAs) in this interaction. Host ncRNAs regulate gene expression and microbiota composition, whereas microbial small RNAs (sRNAs) modulate host gene ...
Ziyi Zhao, Ni Li, Jingyi Xu, Jianrong Ren, Xiaojun Yang, Xinyi Li, Junhu Yao, Shengru Wu   +7 more
wiley   +1 more source

Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1

Nature Communications
The chromatin remodeler ALC1 is activated by DNA damage-induced poly(ADP-ribose) deposited by PARP1/PARP2 and their co-factor HPF1. ALC1 has emerged as a cancer drug target, but how it is recruited to ADP-ribosylated nucleosomes to affect their ...
Luka Bacic, Guillaume Gaullier, Jugal Mohapatra, Guanzhong Mao, Klaus Brackmann, Mikhail Panfilov, Glen Liszczak, Anton Sabantsev, Sebastian Deindl   +8 more
doaj   +1 more source

Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies and replication of grass carp reovirus

Frontiers in Immunology, 2022
Grass carp reovirus (GCRV) is the most pathogenic double-stranded (ds) RNA virus among the isolated aquareoviruses. The molecular mechanisms by which GCRV utilizes host factors to generate its infectious compartments beneficial for viral replication and ...
Jie Zhang, Pengwei Li, Pengwei Li, Riye Lu, Songying Ouyang, Ming Xian Chang, Ming Xian Chang, Ming Xian Chang   +7 more
doaj   +1 more source

Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]

, 2015
Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core  

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Characterization of a novel ADP-ribosylation factor gene from Macrobrachium nipponense and its response to ammonia nitrogen stress

Aquaculture Environment Interactions, 2021
ADP-ribosylation factors (Arfs) are guanosine triphosphate (GTP)-binding proteins that play essential roles in membrane trafficking, and they have been recently reported to be involved in innate immunity in crustaceans.
L Guo, B Sun, D Chen, C Yi, J Teng, J Yu, S Wang, Y Ru, H Wang   +8 more
doaj   +1 more source

The Role of ADP-ribosylation Factor and Phospholipase D in Adaptor Recruitment [PDF]

The Journal of Cell Biology, 1997
AP-1 and AP-2 adaptors are recruited onto the TGN and plasma membrane, respectively. GTPγS stimulates the recruitment of AP-1 onto the TGN but causes AP-2 to bind to an endosomal compartment (Seaman, M.N.J., C.L. Ball, and M.S. Robinson. 1993. J. Cell Biol. 123:1093–1105).
Nicholas A. Bright, Michele A. West, Margaret S. Robinson   +2 more
openaire   +2 more sources

CARF regulates the alternative splicing and piwi/piRNA complexes during mouse spermatogenesis through PABPC1

Acta Biochimica et Biophysica Sinica
ADP-ribosylation factor collaborator (CARF), which is also known as CDKN2AIP, was first recognized as an ADP-ribosylation factor-interacting protein that participates in the activation of the ARF-p53-p21 (WAF1 ...
Cao Yuming, Wang Shengnan, Liu Jie, Xu Jinfeng, Liang Yan, Ao Fei, Wei Zexiao, Wang Li   +7 more
doaj   +1 more source