Results 81 to 90 of about 34,146 (129)
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1989
The molecular mechanism of poly(ADP-ribose) transferase activation following the treatment of mammalian cells with DNA damaging agents is still unknown. Several lines of evidence indicate that the activation process does not require de novo synthesis of the enzyme and that the extent of increase in activity is correlated to the type of DNA damage (1 ...
A. I. Scovassi +4 more
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The molecular mechanism of poly(ADP-ribose) transferase activation following the treatment of mammalian cells with DNA damaging agents is still unknown. Several lines of evidence indicate that the activation process does not require de novo synthesis of the enzyme and that the extent of increase in activity is correlated to the type of DNA damage (1 ...
A. I. Scovassi +4 more
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Pathological and physiological roles of ADP-ribosylation: established functions and new insights
Biological chemistryThe posttranslational modification of proteins with poly(ADP-ribose) was discovered in the sixties. Since then, we have learned that the enzymes involved, the so-called poly(ADP-ribosyl)polymerases (PARPs), are transferases which use cofactor NAD+ to ...
Karla L. H. Feijs-Žaja +2 more
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Analogues of benzamide containing a sulfur atom as poly(ADP-ribose) transferase inhibitors.
Biochemistry international, 1987Structural analogues of benzamide (BA) containing a sulfur atom were tested for their ability to inhibit the enzyme poly(ADP-ribose)transferase (ADPRT) in cultured Chinese Hamster Ovary (CHO) cells. These compounds were benzene sulfonamide (BSA), thiobenzamide (TB) and 3-thiophene carboxamide (TCA) and their activity was compared with that of benzamide
CANTONI, ORAZIO +5 more
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Mutagenesis, 1990
The effect on somatic mutations and recombination by 3-aminobenzamide (3-ABA), an inhibitor of poly(ADP-ribose) transferase, was studied in the somatic wing spot test in Drosophila melanogaster, 3-ABA did not exert any effect by itself, but caused a strong increase of wing spots in combination with methyl methanesulphonate (MMS) and ethylnitrosourea ...
J, Magnusson, C, Ramel
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The effect on somatic mutations and recombination by 3-aminobenzamide (3-ABA), an inhibitor of poly(ADP-ribose) transferase, was studied in the somatic wing spot test in Drosophila melanogaster, 3-ABA did not exert any effect by itself, but caused a strong increase of wing spots in combination with methyl methanesulphonate (MMS) and ethylnitrosourea ...
J, Magnusson, C, Ramel
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Regulation of poly(ADP-ribose) transferase activity by 2',5'-oligoadenylates.
Biochemistry international, 1984pppA2'pA2'pA appears to be a potent natural noncompetitive inhibitor of poly (ADP-ribose) transferase activity in the histone dependent reaction of ADP-ribosylation with Ki=5 microM. Moreover, it is a noncompetitive inhibitor of the Mg2+ dependent reaction of autoADPRT-ribosylation with Ki=20 microM.
A D, Pivazian +6 more
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Biochemical and Biophysical Research Communications, 1984
Rats fed a synthetic diet containing 0.25% benzamide, 0.1% phenobarbital, separately or in combination, for two weeks showed a significant augmentation in the activity of nuclear poly(ADP-ribose) polymerase as well as changes in various nuclear, microsomal and cytosolic liver enzymes involved in the metabolism of xenobiotics.
M J, Griffin +5 more
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Rats fed a synthetic diet containing 0.25% benzamide, 0.1% phenobarbital, separately or in combination, for two weeks showed a significant augmentation in the activity of nuclear poly(ADP-ribose) polymerase as well as changes in various nuclear, microsomal and cytosolic liver enzymes involved in the metabolism of xenobiotics.
M J, Griffin +5 more
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Ukrainskii biokhimicheskii zhurnal (1978), 1986
The (ADP-ribose)n transferase activity of enterocyte nuclei of small intestine is studied in rats in normal and under radiation injury of intestine mucosa. It is shown that kinetics of [14C]-NAD incorporation into the acid-insoluble fraction of enterocyte nuclei is of a two-step character when the medium contains 1-15 microM of NAD.
T B, Trofimiak +3 more
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The (ADP-ribose)n transferase activity of enterocyte nuclei of small intestine is studied in rats in normal and under radiation injury of intestine mucosa. It is shown that kinetics of [14C]-NAD incorporation into the acid-insoluble fraction of enterocyte nuclei is of a two-step character when the medium contains 1-15 microM of NAD.
T B, Trofimiak +3 more
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Understanding Tankyrase Inhibitors and Their Role in the Management of Different Cancer.
Current Cancer Drug TargetsCancer manifests as uncontrolled cell proliferation. Tankyrase, a poly(ADP-ribose) polymerase member, is vital in Wnt signal transmission, making it a promising cancer therapy target. The Wnt/β-catenin pathway regulates critical biological processes like
Sinjini Das +3 more
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The effect of inhibitors of ADP-ribose transferase on the concentration of (ADP-ribose)n in vivo
Biochemical Society Transactions, 1984WILLIAM H. MULLEN +2 more
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Introduction to poly(ADP-ribose) metabolism.
Cellular and molecular life sciences : CMLS, 2005J. Diefenbach, A. Bürkle
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