Results 81 to 90 of about 7,274 (190)

Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2744-2756, April 2026.
Abstract Aims Imeglimin is a novel oral hypoglycemic agent approved for the treatment of type 2 diabetes in Japan, with dual actions to enhance insulin secretion and improve insulin sensitivity, suggested by preclinical evidence. However, the effect of imeglimin on tissue‐specific insulin sensitivity and glucose kinetics using glucose tracers is ...
Tsubasa Tajima, Hideyoshi Kaga, Naoaki Ito, Toshiki Kogai, Hitoshi Naito, Saori Kakehi, Satoshi Kadowaki, Yuya Nishida, Ryuzo Kawamori, Yoshifumi Tamura, Hirotaka Watada   +10 more
wiley   +1 more source

Overcoming multiple drug resistance mechanisms in medulloblastoma [PDF]

, 2014
Introduction: Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients.
Andrey Korshunov, Beth Coyle, Ian D Kerr, Ioanna Kimishi, Lisa CD Storer, Othman, Ramadhan T, Ramadhan RamadhanT Othman, Richard G Grundy, Stefan M Pfister, Tracey D Bradshaw   +9 more
core   +1 more source

The genome and stage‐specific transcriptomes of the carrot weevil, Listronotus oregonensis, reveal adaptive mechanisms for host specialisation and symbiotic interactions

Insect Molecular Biology, Volume 35, Issue 2, Page 126-138, April 2026.
Comprehensive genome and stage‐specific transcriptomes reveal 14,637 genes in Listronotus oregonensis, advancing genetic insights into a key agricultural pest. Compared with related species, L. oregonensis exhibits reduced chemoreceptor gene families but expanded detoxification gene clusters, reflecting its narrow host range and adaptability.
Dave T. Ste‐Croix, Annie‐Ève Gagnon, Benjamin Mimee   +2 more
wiley   +1 more source

Contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements [PDF]

, 2014
Mammalian triokinase, which phosphorylates exogenous dihydroxyacetone and fructose-derived glyceraldehyde, is neither molecularly identified nor firmly associated to an encoding gene.
Cabezas, Alicia, Cameselle, José Carlos, Canales, José, Costas, María Jesús, Couto, Ana, Pinto, Rosa María, Ribeiro, João Meireles, Rodrigues, Joaquim Rui   +7 more
core   +1 more source

Haplotype‐phased ‘Ottawa 3’ genome unravels differential reaction of apple rootstock roots to mixed viral infection

The Plant Journal, Volume 126, Issue 1, April 2026.
SUMMARY Viral diseases pose a significant threat to global apple (Malus spp.) production. While selecting appropriate rootstocks is a crucial strategy to mitigate their effects, the underlying mechanisms governing rootstock tolerance or sensitivity to viral infection at the root level remain underexplored.
Larissa Carvalho Costa, Christopher Gottschalk, Davis M. Upchurch, Oscar P. Hurtado‐Gonzales, Ben N. Mansfeld, Alan Yocca, Lauren Whitt, Cheryl Vann, Gennaro Fazio   +8 more
wiley   +1 more source

Environmental stress reveals new insights regarding proteome rebalancing in Arabidopsis thaliana seeds

The Plant Journal, Volume 126, Issue 2, April 2026.
SUMMARY Seeds are resilient to genetic and envirxonmental perturbation. For example, they can compensate for the loss of highly abundant seed storage proteins (SSPs) while maintaining amino acid levels and composition, a process known as proteome rebalancing.
Huda Ansaf, Clement Bagaza, Abou Yobi, Thomas P. Mawhinney, Ruthie Angelovici   +4 more
wiley   +1 more source

Multiple myeloma and persistence of drug resistance in the age of novel drugs (Review) [PDF]

, 2016
Multiple myeloma (MM) is a mature B cell neoplasm that results in multi-organ failure. The median age of onset, diverse clinical manifestations, heterogeneous survival rate, clonal evolution, intrinsic and acquired drug resistance have impact on the ...
Bebawy, M, Brown, RD, Jaiswal, R, Krishnan, SR, Luk, F   +4 more
core   +1 more source

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity [PDF]

, 2009
Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat or concave.
Janusz Wesolowski, Vanina Alzogaray, Jan Reyelt, Mandy Unger, Karla Juarez, Mariela Urrutia, Ana Cauerhff, Welbeck Danquah, Björn Rissiek, Felix Scheuplein, Nicole Schwarz, Sahil Adriouch, Olivier Boyer, Michel Seman, Alexei Licea, David V. Serreze, Fernando A. Goldbaum, Friedrich Haag, Friedrich Koch-Nolte, OH Brekke, C Hamers-Casterman, S Muyldermans, P Holliger, A Desmyter, E De Genst, TT Wu, MM Harmsen, A Pini, HR Hoogenboom, V Cortez-Retamozo, M Dumoulin, EK Conrath, U Rothbauer, A Olichon, K Coppieters, N Pant, D Gueorguieva, SA Jobling, B Serruys, M Feldmann, N Lonberg, A Drucker, JW Goding, M Salmi, D Corda, A Zolkiewska, F Di Virgilio, F Koch-Nolte, S Adriouch, F Koch-Nolte, F Scheuplein, S Adriouch, M Seman, V Ghetie, G Behar, AJ Groot, A Muruganandam, A Abulrob, V Cortez-Retamozo, K Omidfar, R Roovers, L Huang, BM Tijink, F Rahbarizadeh, D Ahmadvand, MA Palladino, DR Maass, W Wolfson, JJ Hulstein, D Schenk, M Dumoulin, P Lafaye, G Habicht, R Klooster, C Cohen-Saidon, C Avignolo, AJ Groot, AJ Groot, P Verheesen, D Laune, A Marquardt, DA Laplagne, LM Zarebski, DP Simmons, T Gura, K Strebhardt, K Aktories, ER Goldman, JL Liu, ER Goldman, M El Khattabi, RA Harrison, F Meddeb-Mouelhi, RA Harrison, CS Stewart, I Hmila, PJ Doyle, S Spinelli, RC Ladenson, GP Anderson, N Alvarez-Rueda, DM Goldenberg, A Forsman, L Garaicoechea, MM Harmsen, MM Harmsen, A Hultberg, HJ de Haard, AM Ledeboer, S Dekker, LJ Sherwood, MM Harmsen, A Szynol, C Krüger, KV Korotkov, AY Lam, S Spinelli, KE Conrath, B Stijlemans, TN Baral, D Saerens, L Ratier, N Deckers, E Dolk, AS Greenberg, C Vincke, X Zou, R Janssens, EG Hofman, LO Gainkam, F Rahbarizadeh, S Winichayakul, D Saerens, D Saerens, PH Chan, A Chartier, S van Koningsbruggen, JL Liu, JM van der Vaart, MM Harmsen, KA Henderson, W DeLano, RL Stanfield, AT Hadfield, BC Braden, MR Bazl, U Rothbauer   +146 more
core   +4 more sources

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species [PDF]

, 2017
Acquired epilepsies can arise as a consequence of brain injury and result in unprovoked seizures that emerge after a latent period of epileptogenesis. These epilepsies pose a major challenge to clinicians as they are present in the majority of patients ...
Albena Dinkova Kostova, Alexander Herrmann, Ali Gorji, Altmann, Bernardi, Chance, Chance, Dingledine, D’Orsi, Heilbrunn, Henshall, Lux, Nicholls, Nico Melzer, Sacktor, Stjepana Kovac, Sven Meuth   +16 more
core   +3 more sources

Characterization of Sirt2 using conditional RNAi in mice [PDF]

, 2011
Within the past eight years, RNA interference (RNAi) has emerged as a powerful experimental tool for gene function analysis in mice. Reversible control of shRNA mediated RNAi has been achieved by using a tetracycline (tet)-inducible promoter.
Reiss, Martina
core