Results 71 to 80 of about 34,146 (129)
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Poly(ADP-Ribose) Transferase in Lizard Oviduct
1989Poly(ADP-ribose) transferase often undergoes a drastic change in its activity following the action of various biological effectors in a variety of cell systems or tissues. An increase in poly(ADP-ribose) transferase activity was usually observed in those systems in which the biological effectors were followed with cell proliferation, for instance, in ...
Gaetano Ciarcia +2 more
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Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993
We investigated the effects of acid treatment (pH 3.5) on the activities of arginine-specific ADP-ribosyltransferase (mono(ADP-ribosyl)transferase) (EC 2.4.2.31) and poly(ADP-ribose) synthetase (EC 2.4.2.30) purified from chicken liver, and we observed that the former enzyme retained completely its activity while there was no evidence for activity of ...
S, Doi +3 more
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We investigated the effects of acid treatment (pH 3.5) on the activities of arginine-specific ADP-ribosyltransferase (mono(ADP-ribosyl)transferase) (EC 2.4.2.31) and poly(ADP-ribose) synthetase (EC 2.4.2.30) purified from chicken liver, and we observed that the former enzyme retained completely its activity while there was no evidence for activity of ...
S, Doi +3 more
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1989
Investigation of the cellular role of the nuclear protein modification ADP-ribosylation has depended heavily on the use of benzamides as inhibitors of ADP-ribosyl transferase (EC 2.4.2.30) in intact cell studies. The substituted benzamides were first introduced by Whish (1) and have proved to be useful inhibitors of low toxicity and fairly high ...
Christopher J. Skidmore +2 more
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Investigation of the cellular role of the nuclear protein modification ADP-ribosylation has depended heavily on the use of benzamides as inhibitors of ADP-ribosyl transferase (EC 2.4.2.30) in intact cell studies. The substituted benzamides were first introduced by Whish (1) and have proved to be useful inhibitors of low toxicity and fairly high ...
Christopher J. Skidmore +2 more
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Journal of Theoretical Biology, 1993
A model for eukaryotic DNA damage repair is proposed in which poly(ADP-ribose) polymerase(NAD+ ADP-ribosyl transferase, EC 2,4,2,30) plays an important role. In this model, poly(ADP-ribose) polymerase regulates transcription of genes that are induced by DNA-damaging agents.
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A model for eukaryotic DNA damage repair is proposed in which poly(ADP-ribose) polymerase(NAD+ ADP-ribosyl transferase, EC 2,4,2,30) plays an important role. In this model, poly(ADP-ribose) polymerase regulates transcription of genes that are induced by DNA-damaging agents.
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International Journal of Radiation Oncology*Biology*Physics, 1988
Four newly-established human tumor cell lines, have been irradiated at dose rates of 150 and 3.2 cGy/min to compare their capacity to repair radiation damage. They included a neuroblastoma, a germ-cell carcinoma of the testis, a large cell carcinoma of the lung, and a carcinoma of the cervix. The four lines varied in their sensitivity to high dose-rate
L R, Kelland, L, Burgess, G G, Steel
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Four newly-established human tumor cell lines, have been irradiated at dose rates of 150 and 3.2 cGy/min to compare their capacity to repair radiation damage. They included a neuroblastoma, a germ-cell carcinoma of the testis, a large cell carcinoma of the lung, and a carcinoma of the cervix. The four lines varied in their sensitivity to high dose-rate
L R, Kelland, L, Burgess, G G, Steel
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Loss of Poly(ADP-Ribose) Transferase Activity in Liver of Rats Treated with 2-Acetylaminofluorene
1989The chronic exposure of rats to a feeding regimen containing subcarcinogenic doses of N-2-acetylaminofluorene (2AAF) induces, in liver, multiple effects and the progression to hepatocellular carcinoma(s) (1). Among the effects induced at the hepatocellular level, which seem to play a crucial role in the initial steps of the carcinogenic process, are ...
C. F. Cesarone +5 more
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Molecular Carcinogenesis, 1999
The aim of this work was to study the role of the tumor suppressor p53 and of poly(ADP-ribose) transferase (pADPRT) in the control of hepatocyte apoptosis in two different in vivo models, i.e., during the process of tumor initiation by the genotoxin and cytotoxin N-nitrosomorpholine (NNM) and after withdrawal of the hepatomitogen cyproterone acetate ...
J, Weşierska-Gadek +3 more
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The aim of this work was to study the role of the tumor suppressor p53 and of poly(ADP-ribose) transferase (pADPRT) in the control of hepatocyte apoptosis in two different in vivo models, i.e., during the process of tumor initiation by the genotoxin and cytotoxin N-nitrosomorpholine (NNM) and after withdrawal of the hepatomitogen cyproterone acetate ...
J, Weşierska-Gadek +3 more
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Mono-ADP-ribosylating PARP enzymes in cellular signaling and disease
Journal of Cell ScienceADP-ribosyl-transferases (ARTs) are versatile post-translational regulators. Mammalian ARTs include poly- and mono-ADP-ribosylating enzymes, which transfer ADP-ribose molecules deriving from β-NAD+ to their targets.
Simone Di Paola +2 more
semanticscholar +1 more source
1989
Polymerization of ADP-ribose from NAD+ by poly(ADP-ribose) transferase is initiated by auto-mono-ADP-ribosylation of the enzyme followed by ADP-ribose transfer to other acceptor proteins and subsequent elongation (1). DNA is required as a coenzyme, and an enzyme-associated DNA, defined as sDNA (2), can be isolated which is more efficient than crude ...
Alaeddin Hakam +3 more
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Polymerization of ADP-ribose from NAD+ by poly(ADP-ribose) transferase is initiated by auto-mono-ADP-ribosylation of the enzyme followed by ADP-ribose transfer to other acceptor proteins and subsequent elongation (1). DNA is required as a coenzyme, and an enzyme-associated DNA, defined as sDNA (2), can be isolated which is more efficient than crude ...
Alaeddin Hakam +3 more
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1992
Despite the increasing interest on both the physiological and pathological role of ADP-ribosylation reactions, little appears to be known about the mechanism by which the intracellular level of NAD+ is regulated with respect to its participation in the redox metabolism on the one hand and to its utilization in poly(ADP-ribosy)lation on the other ...
N. Raffaelli +6 more
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Despite the increasing interest on both the physiological and pathological role of ADP-ribosylation reactions, little appears to be known about the mechanism by which the intracellular level of NAD+ is regulated with respect to its participation in the redox metabolism on the one hand and to its utilization in poly(ADP-ribosy)lation on the other ...
N. Raffaelli +6 more
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