Results 51 to 60 of about 34,146 (129)

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha‐Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization

Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.
ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley   +1 more source

Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells

Journal of Medicinal Chemistry, 2014
We report the antitumor effects of nitric oxide (NO) releasing derivatives of the PARP-1 inhibitor olaparib (1). Compound 5b was prepared by coupling the carboxyl group of 3b and the free amino group of arylated diazeniumdiolated piperazine 4. Analogue 5a has the same structure except that the F is replaced by H.
Maciag, Anna E., Holland, Ryan J., Kim, Youseung, Kumari, Vandana, Luthers, Christina E., Sehareen, Waheed S., Biswas, Debanjan, Morris, Nicole L., Ji, Xinhua, Anderson, Lucy M., Saavedra, Joseph E., Keefer, Larry K.   +11 more
openaire   +2 more sources

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Tolerance to Phosphorus Deficiency Improves Seed Phytic Acid‐to‐Iron Molar Ratios in Common Bean

Plant, Cell &Environment, Volume 49, Issue 7, Page 4152-4165, July 2026.
ABSTRACT Although significant advances have been achieved in the biofortification of common beans to overcome deficiencies in Zinc (Zn) and iron (Fe), the mechanisms involved remain poorly understood. We thus explored the relationships between phosphorus nutrition and Zn and Fe accumulation in four bean genotypes (Edar, Nizok, Colorado and Chimbolos ...
Barbara Karpinska, Christine H. Foyer
wiley   +1 more source

Structural evolution of the selectivity clamp confers ADPR-PP specificity in Namat, a phage nicotinamide ADP-ribose transferase

Nucleic Acids Research
Abstract Phages and bacteria engage in an evolutionary arms race, in which NAD⁺ depletion serves as a potent bacterial defense. The phage NAD⁺ reconstitution pathway 1 (NARP1) counteracts this strategy via ADP-ribose phosphorylase (Adps) and nicotinamide ADP-ribose transferase (Namat), which restores NAD⁺ by repurposing the products ...
Meimei Lan, Li Xu, Yizhen Han, Tong Cui, Zhi Qiao, Yan-Bin Teng, Na Wang, Hongyu Bao   +7 more
openaire   +2 more sources

B cell intrinsic and extrinsic regulation of antibody responses by PARP14, an intracellular ADP-ribosyltransferase

Journal of Immunology, 2013
The capacity to achieve sufficient concentrations of Ag-specific Ab of the appropriate isotypes is a critical component of immunity that requires efficient differentiation and interactions of Ag-specific B and Th cells along with dendritic cells ...
S. Cho, Ariel L. Raybuck, M. Wei, J. Erickson, K. Nam, Reagan G. Cox, Alyssa Trochtenberg, James W. Thomas, John V. Williams, M. Boothby   +9 more
semanticscholar   +1 more source

Cholix Toxin, a Novel ADP-ribosylating Factor from Vibrio cholerae*

Journal of Biological Chemistry, 2008
The ADP-ribosyltransferases are a class of enzymes that display activity in a variety of bacterial pathogens responsible for causing diseases in plants and animals, including those affecting mankind, such as diphtheria, cholera, and whooping cough.
R. Jørgensen, Alexandra E. Purdy, R. Fieldhouse, M. Kimber, D. Bartlett, A. Merrill   +5 more
semanticscholar   +1 more source

Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo.

Journal of Biological Chemistry, 1989
The ADP-ribosyl moiety of NAD+ is consumed in reactions catalyzed by three classes of enzymes: poly(ADP-ribose) polymerase, protein mono(ADP-ribosyl)transferases, and NAD+ glycohydrolases.
P. Rankin, E. Jacobson, Robert C. Benjamin, Joel Moss, M. Jacobson   +4 more
semanticscholar   +1 more source

Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases.

The Journal of biological chemistry, 1995
Bacterial toxin ADP-ribosyltransferases, e.g. diphtheria toxin (DT) and pertussis toxin, have in common consensus sequences involved in catalytic activity, which are localized to three regions. Region I is notable for a histidine or arginine; region II, approximately 50-75 amino acids downstream, is rich in aromatic/hydrophobic amino acids; and region ...
T, Takada, K, Iida, J, Moss
openaire   +1 more source