Results 31 to 40 of about 135,585 (316)

Post-Mortem Immunohistochemical Evidence of β2-Adrenergic Receptor Expression in the Adrenal Gland [PDF]

, 2019
The evidence from post-mortem biochemical studies conducted on cortisol and catecholamines suggest that analysis of the adrenal gland could provide useful information about its role in human pathophysiology and the stress response.
Alibrandi A., Asmundo A., Baldino G., Cardia L., Macaione V., Malta C., Micali A., Minutoli L., Mondello C., Puzzolo D., Ventura Spagnolo E.   +10 more
core   +1 more source

Single-cell and spatial transcriptomics analysis of human adrenal aging

Molecular Metabolism
Objective: The human adrenal cortex comprises three functionally and structurally distinct layers that produce layer-specific steroid hormones. With aging, the human adrenal cortex undergoes functional and structural alteration or “adrenal aging ...
Norifusa Iwahashi, Hironobu Umakoshi, Masamichi Fujita, Tazuru Fukumoto, Tatsuki Ogasawara, Maki Yokomoto-Umakoshi, Hiroki Kaneko, Hiroshi Nakao, Namiko Kawamura, Naohiro Uchida, Yayoi Matsuda, Ryuichi Sakamoto, Masahide Seki, Yutaka Suzuki, Kohta Nakatani, Yoshihiro Izumi, Takeshi Bamba, Yoshinao Oda, Yoshihiro Ogawa   +18 more
doaj   +1 more source

Critical roles of endogenous glucocorticoids for disease tolerance in malaria

, 2019
During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked.
De Bosscher, Karolien, Opdenakker, Ghislain, Van den Steen, Philippe E., Vandermosten, Leen, Vanhorebeek, Ilse   +4 more
core   +1 more source

CLINICAL CASE OF 19-YEARS-OLD PATIENT WITH CONGENITAL ADRENAL CORTEX DYSFUNCTION

Клиническая практика, 2016
Congenital adrenal hyperplasia is caused by partial or complete block of enzymatic systems involved in the synthesis of steroid hormones of the adrenal cortex and leading to reduced production of glucocorticoids.
S I Ascolskaya, R H Tàzitdinov, Yu V Popov, E L Soyustova, A B Okulov   +4 more
doaj   +1 more source

Adrenal Oncocytic Neoplasm with Paradoxical Loss of Important Mitochondrial Steroidogenic Protein: The 18 kDA Translocator Protein

Case Reports in Endocrinology, 2017
The adrenal glands produce a variety of hormones that play a key role in the regulation of blood pressure, electrolyte homeostasis, metabolism, immune system suppression, and the body’s physiologic response to stress.
Roberto Ruiz-Cordero, Alia Gupta, Arumugam R. Jayakumar, Gaetano Ciancio, Gunnlaugur Petur Nielsen, Merce Jorda   +5 more
doaj   +1 more source

Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The adrenal cortex plays a central role in regulating body homeostasis through production of glucocorticoids and mineralocorticoids that control metabolism, inflammation, and blood pressure.
M. Mathieu, C. Drelon, S. Rodriguez, H. Tabbal, A. Septier, C. Damon-Soubeyrand, T. Dumontet, A. Berthon, I. SAHUT-BARNOLA, C. Djari, M. Batisse-Lignier, Jean-Christophe Pointud, Damien Richard, G. Kerdivel, Marie-Ange Calméjane, V. Boeva, I. Tauveron, A. LEFRANCOIS-MARTINEZ, Antoine Martinez, P. Val   +19 more
semanticscholar   +1 more source

Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]

, 2020
Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian, Bahethi, Rohini, Beule, Dieter, Choi, Murim, Eisenhofer, Graeme, Liebisch, Gerhard, Messerschmidt, Clemens, Obermayer, Benedikt, Peitzsch, Mirko, Scholl, Ute I., Schrade, Petra, Seidel, Eric, Walenda, Gudrun, Wallace, Paal, Yoo, Taekyeong   +14 more
core   +2 more sources

Adrenocortical zonation, renewal, and remodeling

Frontiers in Endocrinology, 2015
The adrenal cortex is divided into concentric zones. In humans the major cortical zones are the zona glomerulosa, zona fasciculata, and zona reticularis.
Marjut ePihlajoki, Julia eDörner, Rebecca S. Cochran, Markku eHeikinheimo, David B Wilson   +4 more
doaj   +1 more source

Pyoderma gangrenosum in a newborn - case report [PDF]

Anais Brasileiros de Dermatologia, 2013
Pyoderma gangrenosum is a rare, inflammatory, chronic and recurrent disease of unknown etiology, characterized by noninfectious, necrotizing and painful cutaneous ulcers.
Francisca Regina Oliveira Carneiro, Maria Amélia Lopes dos Santos, Brena Andrade de Sousa, Carla do Socorro Silva do Nascimento, Gabriela Athayde Amin, Ana Thais Machado Moutinho   +5 more
doaj   +1 more source

Neuroeconomics of suicide. [PDF]

, 2011
Suicidal behavior is a leading cause of injury and death worldwide. Suicide has been associated with psychiatric illnesses such as depression and schizophrenia, as well as economic uncertainty, and social/cultural factors.
Takahashi, Ph.D Taiki
core   +2 more sources