Results 41 to 50 of about 34,051 (260)

Tunable and Sensitive Detection of Cortisol using Anisotropic Phosphorene with a Surface Plasmon Resonance Technique: Numerical Investigation [PDF]

open access: yesarXiv, 2021
Tunable and ultrasensitive surface plasmon resonance (SPR) sensors are highly desirable for monitoring stress hormones such as cortisol, a steroid hormone formed in the adrenal glands in the human body. This paper describes the detection of cortisol using a bimetallic SPR sensor based on highly anisotropic two-dimensional material, i.e., phosphorene ...
arxiv  

Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis)

open access: yesJournal of Medical Primatology, Volume 52, Issue 1, Page 64-78, February 2023., 2023
Abstract Background The cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades. Methods This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature.
Xiantang Li   +5 more
wiley   +1 more source

CLINICAL CASE OF 19-YEARS-OLD PATIENT WITH CONGENITAL ADRENAL CORTEX DYSFUNCTION

open access: yesКлиническая практика, 2016
Congenital adrenal hyperplasia is caused by partial or complete block of enzymatic systems involved in the synthesis of steroid hormones of the adrenal cortex and leading to reduced production of glucocorticoids.
S I Ascolskaya   +4 more
doaj   +1 more source

Stability analysis of a hypothalamic-pituitary-adrenal axis model with inclusion of glucocorticoid receptor and memory [PDF]

open access: yesAIP Conference Proceedings 1798, 020111, 2017, 2016
This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and adrenal glands, distributed time delays are introduced in the mathematical model.
arxiv   +1 more source

Glucocorticoid regulation of diurnal spine plasticity in the murine ventromedial prefrontal cortex

open access: yesJournal of Neuroendocrinology, Volume 34, Issue 12, December 2022., 2022
In mice, the core clock gene Per1 is expressed rhythmically within the ventromedial prefrontal cortex (vmPFC). Deep layer pyramidal neurons within the vmPFC exhibit a diurnal rhythm of dendritic spine density. Both Per1 expression and dendritic spine density are increased during the active phase along with the diurnal peak of glucocorticoid (GC ...
Alex M. Miller   +4 more
wiley   +1 more source

Adrenal Oncocytic Neoplasm with Paradoxical Loss of Important Mitochondrial Steroidogenic Protein: The 18 kDA Translocator Protein

open access: yesCase Reports in Endocrinology, 2017
The adrenal glands produce a variety of hormones that play a key role in the regulation of blood pressure, electrolyte homeostasis, metabolism, immune system suppression, and the body’s physiologic response to stress.
Roberto Ruiz-Cordero   +5 more
doaj   +1 more source

Neural Annotation Refinement: Development of a New 3D Dataset for Adrenal Gland Analysis [PDF]

open access: yesarXiv, 2022
The human annotations are imperfect, especially when produced by junior practitioners. Multi-expert consensus is usually regarded as golden standard, while this annotation protocol is too expensive to implement in many real-world projects. In this study, we propose a method to refine human annotation, named Neural Annotation Refinement (NeAR).
arxiv  

Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics [PDF]

open access: yes, 2016
The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that regulates numerous physiological processes. Disruptions in the activity of the HPA axis are correlated with many stress-related diseases such as post-traumatic stress disorder (PTSD) and major depressive disorder.
arxiv   +1 more source

Mechanistic insights into the primary and secondary alterations of renal ion and water transport in the distal nephron

open access: yesJournal of Internal Medicine, Volume 293, Issue 1, Page 4-22, January 2023., 2023
Abstract The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so, either because of internal kidney dysfunction (primary alteration) or because of some external factors (secondary alteration), leads to pathologies of varying ...
Nahid Tabibzadeh, Gilles Crambert
wiley   +1 more source

Effect of glucocorticoids on bone metabolism in replacement therapy of adrenal insufficiency. Literature review

open access: yesОжирение и метаболизм, 2020
Adrenal insufficiency (AI) is a syndrome caused by disturbance in the synthesis and secretion of hormones of the adrenal cortex, which ensure the vital activity, energy and water-salt homeostasis.
M. Yu. Yukina   +6 more
doaj   +1 more source

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