Tunable and Sensitive Detection of Cortisol using Anisotropic Phosphorene with a Surface Plasmon Resonance Technique: Numerical Investigation [PDF]
Tunable and ultrasensitive surface plasmon resonance (SPR) sensors are highly desirable for monitoring stress hormones such as cortisol, a steroid hormone formed in the adrenal glands in the human body. This paper describes the detection of cortisol using a bimetallic SPR sensor based on highly anisotropic two-dimensional material, i.e., phosphorene ...
arxiv
Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis)
Abstract Background The cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades. Methods This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature.
Xiantang Li+5 more
wiley +1 more source
CLINICAL CASE OF 19-YEARS-OLD PATIENT WITH CONGENITAL ADRENAL CORTEX DYSFUNCTION
Congenital adrenal hyperplasia is caused by partial or complete block of enzymatic systems involved in the synthesis of steroid hormones of the adrenal cortex and leading to reduced production of glucocorticoids.
S I Ascolskaya+4 more
doaj +1 more source
Stability analysis of a hypothalamic-pituitary-adrenal axis model with inclusion of glucocorticoid receptor and memory [PDF]
This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and adrenal glands, distributed time delays are introduced in the mathematical model.
arxiv +1 more source
Glucocorticoid regulation of diurnal spine plasticity in the murine ventromedial prefrontal cortex
In mice, the core clock gene Per1 is expressed rhythmically within the ventromedial prefrontal cortex (vmPFC). Deep layer pyramidal neurons within the vmPFC exhibit a diurnal rhythm of dendritic spine density. Both Per1 expression and dendritic spine density are increased during the active phase along with the diurnal peak of glucocorticoid (GC ...
Alex M. Miller+4 more
wiley +1 more source
The adrenal glands produce a variety of hormones that play a key role in the regulation of blood pressure, electrolyte homeostasis, metabolism, immune system suppression, and the body’s physiologic response to stress.
Roberto Ruiz-Cordero+5 more
doaj +1 more source
Neural Annotation Refinement: Development of a New 3D Dataset for Adrenal Gland Analysis [PDF]
The human annotations are imperfect, especially when produced by junior practitioners. Multi-expert consensus is usually regarded as golden standard, while this annotation protocol is too expensive to implement in many real-world projects. In this study, we propose a method to refine human annotation, named Neural Annotation Refinement (NeAR).
arxiv
Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics [PDF]
The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that regulates numerous physiological processes. Disruptions in the activity of the HPA axis are correlated with many stress-related diseases such as post-traumatic stress disorder (PTSD) and major depressive disorder.
arxiv +1 more source
Abstract The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so, either because of internal kidney dysfunction (primary alteration) or because of some external factors (secondary alteration), leads to pathologies of varying ...
Nahid Tabibzadeh, Gilles Crambert
wiley +1 more source
Adrenal insufficiency (AI) is a syndrome caused by disturbance in the synthesis and secretion of hormones of the adrenal cortex, which ensure the vital activity, energy and water-salt homeostasis.
M. Yu. Yukina+6 more
doaj +1 more source