A unified model for the human response to lipopolysaccharide-induced inflammation [PDF]
arXiv, 2022 This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and anti-inflammatory cytokines (TNF-$\alpha$, IL-6, IL-10), concentrations of corticotropin-releasing hormone (CRH ...
arxiv
Basal Glucose Control in Type 1 Diabetes using Deep Reinforcement Learning: An In Silico Validation [PDF]
IEEE journal of biomedical and health informatics 2020, 2020 People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring have been proven to be effective in achieving closed-loop control, significant challenges still remain due to the ...
arxiv +1 more source
Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis)
Journal of Medical Primatology, Volume 52, Issue 1, Page 64-78, February 2023., 2023 Abstract Background The cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades. Methods This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature.
Xiantang Li +5 more
wiley +1 more source
A Lactation Hormone of the Adrenal Cortex.
Experimental Biology and Medicine, 1933 One of us1 showed that adrenalectomized rats could bear young if treated with cortin. No attempt was made to raise the young. Carr2 found that cortical extract made according to the Swingle and Pfiffner method did not support lactation. Swingle and Pfiffner3 have recently shown that their extract will support lactation in the dog.Extract made according
J. E. Lockwood +2 more
openaire +2 more sources
Tunable and Sensitive Detection of Cortisol using Anisotropic Phosphorene with a Surface Plasmon Resonance Technique: Numerical Investigation [PDF]
arXiv, 2021 Tunable and ultrasensitive surface plasmon resonance (SPR) sensors are highly desirable for monitoring stress hormones such as cortisol, a steroid hormone formed in the adrenal glands in the human body. This paper describes the detection of cortisol using a bimetallic SPR sensor based on highly anisotropic two-dimensional material, i.e., phosphorene ...
arxiv
Development of a transplantable bioartificial adrenal cortex [PDF]
, 2023 Adrenal insufficiency is a life-threatening disease, in which adrenocortical cells fail to produce adequate amount of steroid hormones, mostly glucocorticoids (cortisol) and mineralocorticoids (aldosterone).
Malyukov, Maria
core +1 more source
Glucocorticoid regulation of diurnal spine plasticity in the murine ventromedial prefrontal cortex
Journal of Neuroendocrinology, Volume 34, Issue 12, December 2022., 2022 In mice, the core clock gene Per1 is expressed rhythmically within the ventromedial prefrontal cortex (vmPFC). Deep layer pyramidal neurons within the vmPFC exhibit a diurnal rhythm of dendritic spine density. Both Per1 expression and dendritic spine density are increased during the active phase along with the diurnal peak of glucocorticoid (GC ...
Alex M. Miller +4 more
wiley +1 more source
CLINICAL CASE OF 19-YEARS-OLD PATIENT WITH CONGENITAL ADRENAL CORTEX DYSFUNCTION
Клиническая практика, 2016 Congenital adrenal hyperplasia is caused by partial or complete block of enzymatic systems involved in the synthesis of steroid hormones of the adrenal cortex and leading to reduced production of glucocorticoids.
S I Ascolskaya +4 more
doaj +1 more source
Stability analysis of a hypothalamic-pituitary-adrenal axis model with inclusion of glucocorticoid receptor and memory [PDF]
AIP Conference Proceedings 1798, 020111, 2017, 2016 This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and adrenal glands, distributed time delays are introduced in the mathematical model.
arxiv +1 more source
Sexual Differentiation of Circadian Clock Function in the Adrenal Gland [PDF]
, 2016 Sex differences in glucocorticoid production are associated with increased responsiveness of the adrenal gland in females. However, the adrenal-intrinsic mechanisms that establish sexual dimorphic function remain ill defined. Glucocorticoid production is
Evans, Jennifer A. +5 more
core +2 more sources