Results 151 to 160 of about 41,637 (221)
The Journal of Pharmacology and Experimental Therapeutics, 1982 The alpha-1 and alpha-2 adrenergic effects of cirazoline were evaluated in guinea-pig aorta and field-stimulated guinea-pig ileum, respectively. Cirazoline was found to be a full agonist at alpha-1 receptors having an ED50, dissociation constant (KA) and relative efficacy similar to that of (-)-norepinephrine.
R R, Ruffolo, J E, Waddell
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Alpha-2 Adrenergic Receptor Agonists are Neuroprotective in Experimental Models of Glaucoma
European Journal of Ophthalmology, 2001 PurposeThe glaucomas are characterized by chronic progressive ganglion cell loss over many years. A drug with neuroprotective activity should increase the resistance of retinal ganglion cells (RGC) to chronic stress or injury and therefore enhance survival.
Larry A. Wheeler, Elizabeth Woldemussie
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Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists
, 1988 This chapter extends the discussion provided in Chapter 1 by providing an overview of the development of criteria for subclassification of alpha-adrenergic receptors into alpha-1 vs alpha-2 adrenergic receptor sybtypes and of more recent data suggesting the existence of subtypes of alpha-2 adrenergic receptors.
J. Paul Hieble +3 more
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Interactions between the Effects of Opioid, Serotonin and Alpha-2-Adrenergic Receptor Agonists on Growth Hormone Release in the Male Rat [PDF]
Neuroendocrinology, 1993 In a previous study, we identified a number of negative interactions between the growth hormone (GH)-releasing effects of opioid, α2 and serotonin agonists when given intravenously ...
Ian Chapman +2 more
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Biochemistry, 1988 The alpha 2 adrenergic receptor (AR) inhibits adenylate cyclase via an interaction with Ni, a guanine nucleotide binding protein. The early steps involved in the activation of the alpha 2 AR by agonists and the subsequent interaction with Ni are poorly understood.
William J. Thomsen +2 more
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Effects of an Alpha-2 Adrenergic Receptor Agonist in Spinal Rats
, 1988 It is now several decades that diverse surgical and pharmacological treatments have been employed to prevent and/or ameliorate the sensory motor deficits which ensue an injury to the spinal cord. The restoration of impaired histological and physiologic parameters by compounds which are membrane stabilizers, antiinflammatory, and antioxidant, and which ...
R. Lehrer, J. A. Sleis, N. E. Naftchi
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Molecular Pharmacology, 1987 alpha 2-Adrenergic receptors in calf retina membranes can be specifically labeled with the tritiated antagonist 3H-RX 781094. Saturation binding occurs to a single class of noncooperative sites. The number of sites amounts to 1070 +/- 243 and 935 +/- 178 fmol/mg of protein, and the equilibrium dissociation constants equal 1.8 +/- 0.4 and 3.8 +/- 0.3 nM
A, Convents +3 more
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Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2019 The mechanism of the neuroprotective action of α2-adrenergic receptor agonists in a model of oxygen-glucose deprivation (OGD) in vitro was investigated. Using fluorescent microscopy, immunostaining, inhibitor analysis, and real-time PCR analysis, we demonstrated that OGD evokes a biphasic [Ca2+]i increase in all cells.
S. G. Gaidin +6 more
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Analgesic and Side Effect Profiles of Novel Alpha-2 Adrenergic Receptor Agonists [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2023 Cristina D. Peterson +6 more
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Archives des maladies du coeur et des vaisseaux, 1989 Imidazolines have been proposed as highly selective drugs for alpha 2-adrenergic receptors. However, we have recently showed that the imidazoline ligand 3H-RX 781094 (idazoxan) binds to both alpha 2-receptors and imidazoline guanidinium receptive substance (IGRS) in rabbit renal proximal tubule.
V, Lachaud +4 more
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