Results 171 to 180 of about 41,637 (221)

Plasma thyrotrophin (TSH) response to intrahypothalamic injection of an α2-adrenergic receptor agonist (clonidine)

Acta Endocrinologica, 1986
Abstract. To delineate the site at which the central noradrenergic (NE) system may exert its stimulatory influence on the thyrotrophin (TSH) secretion, plasma TSH concentrations were measured before and after clonidine (an α2-agonist) administration to the hypothalamus of unanaesthetized, unrestrained rats.
Tadao Kakegawa, Mitsuo Suzuki, Koichi Ishikawa   +2 more
openaire   +3 more sources

[Adrenergic receptors and alpha 2 agonists--1) Molecular biological study of adrenoceptors].

Masui. The Japanese journal of anesthesiology, 1997
Molecular biological studies have established classification of adrenergic receptors 40 years after Prof Ahlquist first classified them into alpha and beta. They are now classified into 9 subtypes consisting of 400 to 480 amino acids. They belong to a super-family of G-protein coupled receptors.
Toshiki Mizobe
openaire   +2 more sources

Different sedimentation properties of agonist- and antagonist-labelled platelet alpha2 adrenergic receptors

Biochemical and Biophysical Research Communications, 1981
Abstract Alpha2 adrenergic receptors were solubilized from human platelet particulate preparations with digitonin. The solubilized alpha2 receptors retained the essential binding specificity characteristics of the membrane-bound receptors. The alpha2 receptors could be labelled in platelet membranes with either agonist ([3H]epinephrine) or antagonist
Brian B. Hoffman, Brian B. Hoffman, Marc G. Caron, Marc G. Caron, Thomas Michel, Thomas Michel, Robert J. Lefkowitz, Robert J. Lefkowitz   +7 more
openaire   +3 more sources

Moxonidine, a Mixed a₂‐Adrenergic and Imidazoline Receptor Agonist, Identifies a Novel Adrenergic Target for Spinal Analgesia

Annals of the New York Academy of Sciences, 2003
Abstract: Moxonidine is a mixed a2‐adrenergic and imidazoline receptor agonist with an improved side effect profile compared to clonidine. Intrathecal (i.t.) moxonidine has been found to possess analgesic activity that, in contrast to the majority of a2‐adrenoceptor (a2AR) agonists, does not require activation of the a2AAR subtype, which mediates many
Laura S. Stone, George L. Wilcox, Carolyn A. Fairbanks   +2 more
openaire   +3 more sources

The paradox of α2 adrenergic regulation of prolactin (PRL) secretion. I. the PRL-releasing action of the α2 receptor agonists

Brain Research Bulletin, 1989
Systemic (IV) administration of the alpha 2 receptor agonist clonidine is known to stimulate secretion of PRL and growth hormone (GH) suggesting a stimulatory role of the central alpha 2 receptors in the regulation of the two hormones. The present work confirms this notion for GH but indicates that the alpha 2 agonists stimulate PRL release by a ...
L. Krulich, Thuy Le, Jana Jurčovičová
openaire   +3 more sources

Effect of sleep deprivation on the growth hormone response to the alpha-2 adrenergic receptor agonist, clonidine, in normal subjects

Journal of Neural Transmission, 1997
One night's sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (2 ug/kg iv) in 11 normal men (p < 0.005). This finding may indicate that SD enhances alpha-2 adrenergic receptor function or that the GH response to GH releasing factor is increased by SD.
B. Krishnan, Samarthji Lal, Harvey J. Guyda, George Schwartz, Maureen E. Kiely, N. P. V. Nair, J. X. Thavundayil   +6 more
openaire   +2 more sources

The Effect of Clonidine, an Alpha-2 Adrenergic Receptor Agonist, on Inflammatory Response and Postischemic Endothelium Function During Early Reperfusion in Healthy Volunteers

Journal of Cardiovascular Pharmacology, 2012
Ischemia-reperfusion disturbs endothelial physiology and generates a proinflammatory state. Animal studies showed that clonidine administered prior hypoxia improves posthypoxic endothelial function. To investigate this effect in human, we have assessed the postischemic endothelium function and the proinflammatory state in healthy volunteers with and ...
Jacques Jamart, Maximilien Gourdin, Baudouin Marchandise, Jean-Michel Dogné, Marc De Kock, François Mullier, Bernard Chatelain, Philippe Dubois   +7 more
openaire   +4 more sources

Alpha-2 Adrenergic and Imidazoline Receptor Agonists: Clonidine, Dexmedetomidine, and Related Antihypertensives, Decongestants, and Sedatives

, 2016
Anthony J. Tomassoni
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[Adrenergic receptor and alpha 2 agonist--4: Applied and clinical pharmacology of alpha 2 agonist].

Masui. The Japanese journal of anesthesiology, 1997
Alpha 2 adrenergic agonists currently are used in the anesthetic management of the surgical patient for their sedative/hypnotic, anesthetic-sparing, analgesic, and sympatholytic properties. Experimental and clinical studies have progressed to the point where anesthesiologists are now focusing on the use of these agents for their analgesic and ...
openaire   +1 more source

[Radiation-protective effect of agonists of alpha-2 adrenergic receptors. Methyldopa].

Radiatsionnaia biologiia, radioecologiia, 1997
MethylDOPA has the considerable (60-80%) and lasting RPE at both intraperitoneal (0.5-3.8 mmol/kg) and per os (3.8-7.1 mmol/kg) introduction in radiation dose 8 Gr (LD97/30). Optimal time for introduction is 0.5-3.0 hours intraperitoneally and 3-6 hours per os. Evidently, methylDOPA RPE is realized via alpha 2-adrenoceptors.
V I, Kulinskiĭ, V Iu, Kovtun, V G, Iashunskiĭ, A L, Klimova   +3 more
openaire   +1 more source