Results 191 to 200 of about 42,588 (295)

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji, Ehud Karavani, Michael Danziger, Pengyue Zhang, Yuan Hou, Yadi Zhou, Marina Bykova, Andrew A. Pieper, Michal Rosen‐Zvi, Jeffrey Cummings, Feixiong Cheng   +10 more
wiley   +1 more source

The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract. [PDF]

World J Urol
Ückert S, Hedlund P, Tsikas D, Kuczyk MA.   +3 more
europepmc   +1 more source

Cell-based and virtual fragment screening for adrenergic a2C receptor agonists [PDF]

, 2015
Bobok, Amrita, Keserű, György Miklós, Kiss, László, Kurkó, Dalma, Szőllősi, Edit, Vass, Márton   +5 more
core   +1 more source

Locus coeruleus alterations in dementia with Lewy bodies: A systematic review

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is a small nucleus located deep within the brainstem, serving as the brain's main source of noradrenergic neurons. Through its extensive projections, it plays a critical role in regulating cognitive processes and arousal.
Anaëlle Bain, Charlotte Tomeo, Claire André, Antoine Garnier‐Crussard, Robin de Flores, Sophie Dautricourt   +5 more
wiley   +1 more source

Is General Anesthesia Safe for a Child with Acute Upper Respiratory Tract Infection? A Narrative Review. [PDF]

Pediatr Rep
Rosada-Kurasińska J, Bartkowska-Śniatkowska A, Wiernik A, Kociński B, Grześkowiak M.   +4 more
europepmc   +1 more source

Avenanthramide C From Oats Possibly Exerts Anti‐Inflammatory Effects in Human Umbilical Vein Endothelial Cells

Journal of Food Science, Volume 91, Issue 1, January 2026.
ABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Hiroyuki Sasaki, Hirofumi Masutomi, Hajime Nagasawa, Yuma Matsumoto, Teruyuki Okuma, Tomoyuki Otsuka, Katsuyuki Ishihara, Yusuke Suzuki, Seiji Ueda   +8 more
wiley   +1 more source

Pharmacotherapy for Cannabis Use Disorder: Preclinical and Clinical Models. [PDF]

Curr Top Behav Neurosci
Bedillion MF, Moore CF, Weerts EM, Arout CA, Harris HM, Haney M.   +5 more
europepmc   +1 more source

Haemodynamic Changes After Prophylactic Doses of Ephedrine, Phenylephrine, Norepinephrine Versus Placebo During Induction of General Anaesthesia: A Randomised Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 1, January 2026.
ABSTRACT Background Ephedrine, phenylephrine, and norepinephrine are commonly used to manage hypotension during the induction of anaesthesia. The objective of this study was to evaluate whether prophylactic administration of assumed equipotent doses of these vasopressors could maintain systolic arterial blood pressure (SAP) and heart rate (HR) within ...
Gunnar Helge Sjøen, Tor Hugo Hauge, Ragnhild Sørum Falk, Tor Inge Tønnessen, Eldrid Langesæter   +4 more
wiley   +1 more source

From Pharmacological Treatment to Neuromodulation: A Comprehensive Approach to Managing Gilles de la Tourette Syndrome. [PDF]

Int J Mol Sci
Monfrini E, Saleh C, Servello D, Jaszczuk P, Porta M.   +4 more
europepmc   +1 more source