Results 131 to 140 of about 101,334 (285)
Vasoconstrictive versus Vasodilatory Effects of Alpha-2 Adrenergic Agonists on the Spinal Microcirculation [PDF]
, 2000 Hiroki Iida +4 more
openalex +1 more source
The FEBS Journal, EarlyView.Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain +2 more
wiley +1 more source
Perirenal Fat in Disease Progression: From Inflammatory Mediator to Therapeutic Target
International Journal of Urology, EarlyView.ABSTRACT Perirenal fat (PRF), the adipose tissue that encases the kidneys, has long been considered a passive energy reservoir and mechanical buffer. However, emerging evidence has identified PRF as a biologically active visceral fat depot that secretes adipocytokines, inflammatory mediators, and other bioactive molecules, and thereby contributes to ...
Eiji Kashiwagi
wiley +1 more source
Journal of Neuroendocrinology, EarlyView.Abstract Recent studies have shown a link between disrupted circadian rhythms and the development of chronic opioid‐induced negative effects. Both animal and human studies show a significant bidirectional relationship between the circadian system and opioid effects.
Nasrin Mehranfard +2 more
wiley +1 more source
L-Tetrahydropalamatine: A Potential New Medication for the Treatment of Cocaine Addiction [PDF]
, 2012 Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine ...
Mantsch, John R., Wang, Jia Bei
core +1 more source
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source
Alpha-1 Adrenergic Agonists for the Prevention of Floppy Iris Syndrome [PDF]
, 2013 Gianluca Carifi, Nikolaos Kopsachilis
openalex +1 more source
Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia.
Cochrane Database of Systematic Reviews, 2015 S. R. Lewis +3 more
semanticscholar +1 more source
The pharmacotherapeutic potential of neuropeptide Y for chronic pain
Journal of Internal Medicine, EarlyView.Abstract Chronic pain is a major medical problem that requires new therapeutic options. Discovered by Victor Mutt in 1982, neuropeptide Y (NPY) is rapidly emerging as a master regulator of pain relief. Genetic knockdown of NPY or pharmacological inhibition of its receptors demonstrates that NPY signaling tonically inhibits indices of chronic ...
Al A. Nie, Bradley K. Taylor
wiley +1 more source