Results 141 to 150 of about 984,866 (243)

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

Update on Sedation for Upper Gastrointestinal Endoscopy in Japan: Current Evidence on Remimazolam

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Sedation is an essential component of upper gastrointestinal endoscopy because it reduces patient discomfort and anxiety while improving patient acceptance and procedural quality. In Japan, benzodiazepines such as midazolam and opioid analgesics have long been widely used in routine clinical practice; however, many of these agents historically
Ryoji Ichijima, Masahiro Toyama, Taiki Shishido, Yuki Koyo, Takehiro Yoshii, Reona Kawamura, Tsubasa Ishikawa, Yasuhiko Mizuguchi, Naoya Toyoshima, Hiroyuki Takamaru, Masayoshi Yamada, Masau Sekiguchi, Seiichiro Abe, Yutaka Saito   +13 more
wiley   +1 more source

Cutaneous‐only hypersensitivity reaction presumed due to intravenous administration of atracurium in a dog

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Summary There are limited case reports of hypersensitivity reactions to neuromuscular blocking agents (NMBAs) in veterinary species, and none describe cutaneous‐only signs. This case report describes a Grade 1 cutaneous‐only hypersensitivity reaction to atracurium in a 7‐year‐old dog undergoing general anaesthesia for cataract surgery with bilateral ...
Kar Yee Phoon, Rob Ward
wiley   +1 more source

Notes on the founding and membership of the Alpha Rho and BKΩ chapters of AKA, undated

, 1970
Notes narrating the history of the Alpha Rho and BKΩ chapters of Alpha Kappa Alpha, along with memberships lists from various years.Archival master image scanned in reflective mode as 48-bit RGB color TIFF using Epson 11000 XL. Display image is 8-bit 150
Alpha Kappa Alpha
core  

Ephedrine for Reducing Onset Time of Rocuronium in Elderly Patients: A Randomised Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 10, November 2026.
ABSTRACT Introduction Onset time of rocuronium is prolonged in elderly patients compared to younger patients. Ephedrine reduces onset time of rocuronium in younger adults, but in elderly patients, the effect of ephedrine on onset time of rocuronium has not been investigated.
Matias Vested, Magnus Fuhr Hovind, Tatiana Nielsen, Sarah Sofie Wadland, Mikkel Helmuth Jensen, Andreas Rodriguez Slente, Karl Peter Damgaard Madsen, Kamilla Skovmand, Fabio Rosa, Charlotte Albrechtsen, Lars Simon Rasmussen   +10 more
wiley   +1 more source

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10459-10474, November 2026.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source