Results 161 to 170 of about 984,866 (243)

Adrenergic receptors: a key determinant of outcomes in bacterial pneumonia and bacterial sepsis-associated acute lung injury/acute respiratory distress syndrome through participation in pulmonary innate immune response. [PDF]

Front Immunol
Zeng L, Yang J, Yan J.
europepmc   +1 more source

Shear Stress‐Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
The vasculo‐splenic axis during exercise: shear stress triggers the release of medium/large extracellular vesicles from vascular endothelial cells via activation of Piezo1, shuttling Piezo1 to the smooth muscle cells in the splenic capsule; the translocated Piezo1 within the splenic capsule acts as a downstream effector of the α1‐adrenergic receptor ...
Jing Lou, Mingzong Yang, Yang Hu, Xuyun Liu, Han Li, Zihang Feng, Yuxin Xi, Changyang Xing, Lijun Yuan, Jia Li, Shengpeng Wang, Feng Gao, Xing Zhang   +12 more
wiley   +1 more source

Xylazine-induced diuresis in rats is attenuated by κ-opioid receptor and α2-adrenoceptor antagonists. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Inan S, Rawls SM.
europepmc   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Preventive Effect of Preoperative Intranasal Dexmedetomidine for Postoperative Delirium in Elderly Patients with Sleep Disorders Undergoing Major Noncardiac Surgery: A Randomized, Triple-Blind, Placebo-Controlled Trial

Drug Design, Development and Therapy
Chao Chen,1,2,* Ruixue Zhai,1,2,* Shengfeng Yang,3,* Xinglong Xiong,1,2 Jun Lu,1,2 Guangling Tang,1,2 Sijie Tang,1,2 Yewei Shi,1,2 Zhenyan Zhu,1,2 Dongxu Chen,4 Jing Shi1,2 1Department of Anesthesiology, Affiliated Hospital of ...
Chen C, Zhai R, Yang S, Xiong X, Lu J, Tang G, Tang S, Shi Y, Zhu Z, Chen D, Shi J   +10 more
doaj  

Comparison of the Utility of Amplitude-Spectral and Coherence Features of Psychotropic Drugs' Action on ECoG Signal for Pharmaco-EEG Based Drug Screening in Rats. [PDF]

Methods Protoc
Sysoev YI, Kurmazov NS, Shitc DD, Okovityi SV.   +3 more
europepmc   +1 more source

Constitutively active mutants of the alpha 2-adrenergic receptor.

, 1993
We have mutated a single residue, Thr373 [corrected], in the C-terminal portion of the third intracellular loop of the alpha 2C10-adrenergic receptor into five different amino acids.
Cotecchia, S., Kurose, H., Ren, Q., Lefkowitz, R.J.   +3 more
core  

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Impact of combined Hydrus Microstent implantation and cataract surgery on diurnal intraocular pressure range: a longitudinal, retrospective study. [PDF]

BMC Ophthalmol
Thelen P, Reinhard T, Helmers G, Böhringer D, Lübke J, Keye P.   +5 more
europepmc   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source