Brimonidine Beyond a Single Specialty: Pharmacological Profile, Dermatologic Applications, and Advances in Drug Delivery Systems. [PDF]
Int J Mol SciJóźwiak W +3 more
europepmc +1 more source
Brain and Behavior, Volume 16, Issue 8, August 2026.Abstract Purpose Ischemic stroke poses a major global health burden, and growing evidence points to the microbiota–gut–brain axis as an important contributor to stroke pathophysiology and recovery. The purpose of this review is to summarize current knowledge on bidirectional gut‐brain communication in stroke, establishing gut dysbiosis as an upstream ...
Ruihui Weng +3 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar +8 more
wiley +1 more source
Xylazine Exposure and Association With Early Physiological and Withdrawal Symptoms in People With Opioid Use Disorder. [PDF]
J Addict MedStrickland JC +6 more
europepmc +1 more source
Targeted Interventions in HAM/TSP: Emerging Therapies and Future Directions – A Narrative Review
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aim Human T‐Lymphotropic virus type 1 (HTLV‐1) infection can lead to HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neurological disease characterized by progressive lower limb spasticity and autonomic dysfunction.
Meygol Mirzaei Rezaei +11 more
wiley +1 more source
An Explorative Approach to Examining the Role of Ischemia and Inflammation on the Function of Autoantibodies Against G Protein-Coupled Receptors and Their Corresponding Agonists. [PDF]
Int J Mol SciWallukat G +4 more
europepmc +1 more source
Metabolic Regulation of Macrophages in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso +3 more
wiley +1 more source
Advances in the Association Between the <i>ADRB2</i> Gene and Bronchial Asthma: Genetic Polymorphisms, Epigenetic Regulation, and Clinical Applications. [PDF]
Curr Issues Mol BiolSun X, Li Y, Bao Y.
europepmc +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT Opioids, most intravenous anesthetics and various illicit substances can cause fatal respiratory depression by depressing central respiratory networks. ENA‐001, a ventilatory modulator targeting the carotid bodies, has emerged as a potential countermeasure without impairing analgesia or hypnosis.
Jimmy J. Arevalo +9 more
wiley +1 more source