Results 101 to 110 of about 53,199 (316)

Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood. Objectives The aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers ...
Kalle J. Niemi, Valtteri Kaasinen, Rimona S. Weil, Juho Joutsa   +3 more
wiley   +1 more source

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease [PDF]

, 2013
The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells.
Brunton, Donald H Maurice, Dreiza, George S Baillie, Hayes, Li, Louisa CY Lee, Shenoy, Tavalin   +8 more
core   +1 more source

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Bladder Function and Safety of Vibegron in Men With Overactive Bladder Receiving Treatment for Benign Prostatic Hyperplasia: Outcomes From the Phase 3 Randomized Controlled COURAGE Trial

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose Vibegron was associated with improvements in efficacy versus placebo and was well tolerated in men with overactive bladder (OAB) on pharmacotherapy for benign prostatic hyperplasia (BPH) in the COURAGE trial (NCT03902080). Additional safety, bladder function, and urodynamics data are provided.
Eric S. Rovner, Janet Owens‐Grillo, Elizabeth Thomas, Sender Herschorn, Kenneth M. Peters, David Staskin, Salim Mujais   +6 more
wiley   +1 more source

Multi-center, prospective, non-interventional, observational study on the efficacy and safety of Mirabek® in adult patients with overactive bladder [PDF]

Investigative and Clinical Urology
"Purpose: Mirabegron, the first-in-class beta-3 agonist, is the mainstay medication for overactive bladder (OAB). The aim of this study was to investigate the efficacy and safety of generic drugs of mirabegron (Mirabek®) in adults diagnosed with OAB ...
Jee Soo Park, Won Sik Jang, Jongchan Kim, Moon-Hwa Park, Won Sik Ham   +4 more
doaj   +1 more source

Ractopamine HCl improved cardiac hypertrophy but not poor growth, metabolic inefficiency, or greater white blood cells associated with heat stress in concentrate-fed lambs [PDF]

, 2019
Heat stress decreases livestock performance and well-being (Hahn, 1999; Nienaber and Hahn, 2007), causes metabolic dysfunction that decreases growth efficiency (O’Brien et al., 2010), and alters cardiovascular function (Crandall et al., 2008). Each year,
Beede, Kristin A., Eggleston, Morgan L., Freeman, Micayla D., Petersen, Jessica L., Schmidt, Ty B., Swanson, Rebecca M., Yates, Dustin T.   +6 more
core   +1 more source

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike, Cerdá-Reverter, José Miguel, Heyder, Nicolas, Kleinau, Gunnar, Krude, Heiko, Kwiatkowski, Dennis, Kühnen, Peter, Scheerer, Patrick, Soletto, Lucia, Speck, David, Szczepek, Michal   +10 more
core   +1 more source

Heart‐On‐a‐Chip with Integrated Ultrasoft Mechanosensors for Continuous Measurement of Cell‐ and Tissue‐Scale Contractile Stresses

Small, EarlyView.
We present a heart‐on‐a‐chip platform embedded with ultrasoft mechanosensors for real‐time, multi‐scale stress mapping in engineered cardiac tissues. The system enables simultaneous quantification of local cell‐generated stresses and global tissue contractile forces.
Ali Mousavi, Christina‐Marie Boghdady, Shihao Cui, Sabra Rostami, Amid Shakeri, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Milica Radisic, Christopher Moraes, Houman Savoji   +10 more
wiley   +1 more source

Rabbit models of heart disease. [PDF]

, 2008
Human heart disease is a major cause of death and disability. A variety of animal models of cardiac disease have been developed to better understand the etiology, cellular and molecular mechanisms of cardiac dysfunction and novel therapeutic strategies ...
Bers, Donald M, Pogwizd, Steven M
core  

Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. [PDF]

, 2018
Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically challenging ...
Baikoghli, Mo, Cheng, R Holland, Coleman, Matthew A, He, Wei, Patriarchi, Tommaso, Shen, Ao, Tian, Lin, Xiang, Yang K   +7 more
core   +2 more sources