Results 111 to 120 of about 53,199 (316)

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Angiotensin II Attenuates the Bioactivities of Human Endothelial Progenitor Cells via Downregulation of β2-Adrenergic Receptor

Stem Cells International, 2018
Cross talks between the renin-angiotensin system (RAS), sympathetic nervous system, and vascular homeostasis are tightly coordinated in hypertension.
Seon Jin Lee, Da Yeon Kim, Jisoo Yun, Sung Hyun Choi, Seok Yun Jung, Songhwa Kang, Ji Hye Park, Yeon Ju Kim, Jong Seong Ha, Seung Taek Ji, Woong Bi Jang, Dong Hyung Lee, Dongjun Lee, Sang-Mo Kwon   +13 more
doaj   +1 more source

Prognostic significance of beta-adrenergic receptor expression in oesophageal adenocarcinoma. [PDF]

J Pathol Clin Res
Abstract Expression of the β‐adrenergic receptors' family has been associated with survival outcomes in multiple different cancer types, showing their potential to act as prognostic factors. No previous work has evaluated these receptors in relation to survival in oesophageal adenocarcinoma.
Oliveira T, Sasi S, Trainor J, McManus DT, McQuaid S, Lewis C, James JA, Coleman HG, McMenamin ÚC, Turkington RC.   +9 more
europepmc   +2 more sources

The cardiovascular effects of beta adrenergic agonist drugs administered by nebulization [PDF]

, 1991
James Hall
openalex   +1 more source

Heteroreceptor complexes and their allosteric receptor-receptor interactions in the central nervous system. Focus on examples from Dopamine D2 and Serotonin 5-HT1a receptors [PDF]

, 2018
GPCR interacting proteins (specially β- arrestin) and their receptor-protein interactions are also covered but their interactions with the allosteric receptor-receptor interactions in heteroreceptor complexes remain to be elucidated.
Corrales Ferro, Fidel
core   +1 more source

The impact of growth promoters on muscle growth and the potential consequences for meat quality [PDF]

, 2016
To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption.
Aalhus, Adeola, Altarejos, Beermann, Beermann, Bodine, Bohorov, Boisclair, Brameld, Brameld, Brooke, Brown, Bush, Casas, Choe, Ciobanu, Clemmons, Coux, Cruzen, Daughaday, David M. Brown, Denley, Douillard, Duckett, Dunshea, Dunshea, Etherton, Etherton, FAO, Foresight, Fuentes-Prior, Geesink, Glass, Godfray, Goll, Goll, Goncalves, Gunawan, Hemmings, Henckel, Higgins, Hocquette, Hopkins, Houbak, Huang, Huang, John M. Brameld, Karlsson, Kemp, Kemp, Kevin J.P. Ryan, Kim, Kim, Koohmaraie, Koopman, Kretchmar, Krick, Krystal M. Hemmings, Lamare, Lametsch, Larzul, Lefaucheur, Liang, Mareko, Mareko, McNeel, Meersman, Mills, Molebeledi H.D. Mareko, Nonneman, Oksbjerg, Ouali, Page, Parr, Parr, Parr, Patience, Peters, Renand, Robert, Ryan, Ryu, Schiaffino, Sensky, Sentandreu, Seppelt, Siegel, Solomon, Taillandier, Tang, Taylor, Taylor, Tim Parr, Tomas, Underwood, Vann, Velloso, Wang, Wendt, Wheeler, Whipple, White   +101 more
core   +1 more source

3,4‐Methylenedioxymethamphetamine (MDMA) does not induce robust psychomotor activation and 50‐kHz ultrasonic vocalisations in tryptophan hydroxylase 2 (Tph2)‐deficient rats lacking serotonin in the central nervous system

British Journal of Pharmacology, EarlyView.
Background and Purpose 3,4‐Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a psychostimulant with entactogenic properties and known to induce arousal and euphoria. As an amphetamine derivate, MDMA acts on the monoamine systems in the brain and stimulates release of dopamine (DA), noradrenaline (NA) and serotonin (5‐HT), yet their ...
Tianhua Wang, Rainer K. W. Schwarting, Markus Wöhr   +2 more
wiley   +1 more source

Supplementary Figure Legend from Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

, 2023
Richard J. Rickles, Winnie F. Tam, Thomas P. Giordano, Laura Pierce, Melissa Farwell, Douglas W. McMillin, Antoaneta S. Necheva, David M. Crowe, Mei Chen, William Avery, Vikram Kansra, Steffan T. Nawrocki, Jennifer S. Carew, Francis J. Giles, Constantine S. Mitsiades, Alexis A. Borisy, Kenneth C. Anderson, Margaret Lee   +17 more
openalex   +1 more source

GDF15: Anxiety Signalling From the Adipose Tissue

iNew Medicine, EarlyView.
Song‐Yang Zhang
wiley   +1 more source