Results 161 to 170 of about 92,710 (320)

A truncation mutation in the avian beta-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors.

, 1990
Cornelia Hertel, Mary H. Nunnally, Sui‐Lam Wong, E. Angela Murphy, E M Ross, J P Perkins   +5 more
openalex   +1 more source

β3‐Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta

Medicinal Research Reviews, Volume 45, Issue 3, Page 842-866, May 2025.
ABSTRACT At different stages of life, from embryonic to postnatal, varying oxygen concentrations modulate cellular gene expression by enhancing or repressing hypoxia‐inducible transcription factors. During embryonic/fetal life, these genes encode proteins involved in adapting to a low‐oxygen environment, including the induction of specific enzymes ...
Luca Filippi, Francesca Innocenti, Francesca Pascarella, Rosa Teresa Scaramuzzo, Riccardo Morganti, Paola Bagnoli, Maurizio Cammalleri, Massimo Dal Monte, Maura Calvani, Alessandro Pini   +9 more
wiley   +1 more source

The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea, Mauro Siragusa, Ingrid Fleming   +2 more
wiley   +1 more source

Supplementary Figures 1 - 10 from Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

, 2023
Richard J. Rickles, Winnie F. Tam, Thomas P. Giordano, Laura Pierce, Melissa Farwell, Douglas W. McMillin, Antoaneta S. Necheva, David M. Crowe, Mei Chen, William Avery, Vikram Kansra, Steffan T. Nawrocki, Jennifer S. Carew, Francis J. Giles, Constantine Mitsiades, Alexis A. Borisy, Kenneth C. Anderson, Margaret Lee   +17 more
openalex   +2 more sources

Adrenergic blockers, statins, and non-steroidal anti-inflammatory drugs are associated with later age at onset in Parkinson's disease. [PDF]

J Neurol
Malatt C, Maghzi H, Hogg E, Tan E, Khatiwala I, Tagliati M.   +5 more
europepmc   +1 more source

Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo

British Journal of Pharmacology, Volume 182, Issue 9, Page 1975-1988, May 2025.
Background and Purpose Dysfunction of the autonomic nervous system is associated with cardiovascular dysfunction, including metabolic syndrome and obesity. Understanding mechanisms of neurogenic control of white adipose tissue is key to understanding adipose physiology and pathophysiology, though there is limited research exploring this in adipose ...
Kayleigh E. Goddard, Samuel J. Fountain
wiley   +1 more source

Effects of insulin‐induced hypoglycaemia on cardiac function in people with type 1 and type 2 diabetes and people without diabetes

Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2768-2776, May 2025.
Abstract Aims Cardiovascular disease is the most common complication and cause of death in people with diabetes. Hypoglycaemia is independently associated with the development of cardiovascular complications, including death. The aim of this study was to assess changes in cardiac function and workload during acute hypoglycaemia in people with and ...
Therese Wilbek Fabricius, Clementine Verhulst, Cecilie Hornborg Svensson, Malene Wienberg, Anthonie L. Duijnhouwer, Cees J. Tack, Peter L. Kristensen, Bastiaan E. de Galan, Ulrik Pedersen‐Bjergaard, on behalf of the Hypo‐RESOLVE consortium   +9 more
wiley   +1 more source

Biological mechanisms of dopamine D₂-like receptor agonist therapy in diabetes. [PDF]

Front Endocrinol (Lausanne)
Freyberg Z, Codario RA.
europepmc   +1 more source

Probing Native CB2 Receptor Mobility in Plasma Membranes of Living Cells by Fluorescence Recovery After Photobleaching

ChemBioChem, Volume 26, Issue 8, April 14, 2025.
The study investigates CB2 receptor (CB2R) mobility in live cells using the fluorescent probe RO7304924 and fluorescence recovery after photobleaching (FRAP). Results demonstrate the probe‘s efficiency in quantifying receptor diffusion and mobility, with CB2R showing high mobile fractions and diffusion coefficients.
Francesca Ciaramellano, Alessandro Leuti, Alexandrine D. E. Kurtz, Roman Sarott, Matthias Westphal, Patrick Pfaff, Uwe Grether, Erick M. Carreira, Mauro Maccarrone, Sergio Oddi   +9 more
wiley   +1 more source

Dezocine and Addiction: Friend or Foe? [PDF]

Pharmaceuticals (Basel)
Childers W, Elokely K, Abou-Gharbia M.
europepmc   +1 more source