Results 11 to 20 of about 50,860 (258)

Functional alteration of the beta-adrenergic receptor during desensitization of mammalian adenylate cyclase by beta-agonists. [PDF]

Proceedings of the National Academy of Sciences, 1984
Exposure of several mammalian cell lines to isoproterenol resulted in a desensitization of the beta-adrenergic receptor-adenylate cyclase system in membranes isolated from the cells. Under the experimental conditions chosen, desensitization was accompanied by a minimal loss of beta-receptors.
S, Kassis, P H, Fishman
openaire   +2 more sources

Beta-Adrenergic Agonists

Pharmaceuticals, 2010
Inhaled β2-adrenoceptor (β2-AR) agonists are considered essential bronchodilator drugs in the treatment of bronchial asthma, both as symptoms-relievers and, in combination with inhaled corticosteroids, as disease-controllers.
Giovanni Barisione, Michele Baroffio, Emanuele Crimi, Vito Brusasco   +3 more
doaj   +1 more source

LBMON186 Beta-agonist Profiling Reveals Novel Biased Signaling Phenotypes For The Beta 2-adrenergic Receptor With Implications In The Treatment Of Asthma

Journal of the Endocrine Society, 2022
Abstract Asthma involves chronic airway inflammation and airway smooth muscle (ASM) cell contraction. Treatment include agonists of the beta 2-AR, a GPCR that induces the Gs/cAMP pathway leading to ASM relaxation. These agonists can also promote severe side effects which have been correlated with beta-arrestins (barr) activation ...
Pascali, Francesco D, Ippolito, Michael, Wolfe, Emily, Komolov, Konstantin E, Hopfinger, Nathan, Lemenze, Douglas, Kim, Nicholas, Armen, Roger S, An, Steven S, Scott, Charles P, Benovic, Jeffrey L   +10 more
openaire   +1 more source

Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists.

Journal of Lipid Research, 1981
The aim of this study was to define the role of the alpha-adrenergic receptor in the regulation of lipolysis by human adipocytes. Glycerol production by isolated human adipocytes was stimulated by the pure beta-adrenergic agonist isoproterenol in a dose ...
E E Wright, E R Simpson
doaj   +1 more source

Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer's Disease

Neurobiology of Disease, 2020
Adrenergic systems regulate both cognitive function and immune function. The primary source of adrenergic signaling in the brain is norepinephrine (NE) neurons of the locus coeruleus (LC), which are vulnerable to age-related degeneration and are one of ...
Andrew K. Evans, Pooneh M. Ardestani, Bitna Yi, Heui Hye Park, Rachel K. Lam, Mehrdad Shamloo   +5 more
doaj   +1 more source

Comparative Pharmacoepidemiological Assessment of Antihypertensive Drugs Administration Structure in Pregnant Women in Routine Medical Practice in Kursk and Chisinau

Рациональная фармакотерапия в кардиологии, 2022
Aim. To study the structure of antihypertensive drugs prescription in pregnant women in routine practice in Kursk and Chisinau.Material and methods. The study design was observational descriptive cross-sectional.
S. V. Povetkin, V. I. Gikavyj, N. G. Bachinski, O. V. Levashova, A. A. Kornilov, L. A. Podgurski, L. M. Tsurkan   +6 more
doaj   +1 more source

β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations [PDF]

, 2014
Background: The NF-kappa B signaling pathway orchestrates many of the intricate aspects of neuroinflammation. Astrocytic beta(2)-adrenergic receptors have emerged as potential regulators in central nervous system inflammation and are potential targets ...
Aerts, Joeri L, De Keyser, Jacques, Demol, Frauke, Gerlo, Sarah, Laureys, Guy, Spooren, Anneleen   +5 more
core   +3 more sources

The (--)[3H]dihydroalprenolol binding to rat adipocyte membranes: an explanation of curvilinear Scatchard plots and implications for quantitation of beta-adrenergic sites

Journal of Lipid Research, 1982
In rat adipocyte membranes, both beta-adrenergic agonists and beta-adrenergic antagonists competed with (--)[3H]dihydroalprenolol for high affinity (KD 2-4 nM) and low capacity binding sites.
E M Dax, J S Partilla, R I Gregerman
doaj   +1 more source

Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. [PDF]

, 2016
BackgroundClenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in
Chouicha, Nadira, Harrison, Linda M, Kass, Phil H, Knych, Heather K, Steinmetz, Stacy J   +4 more
core   +1 more source

Safety and efficacy of beta-3 adrenergic agonists in treating neurogenic lower urinary tract dysfunction: A systematic review and meta-analysis [PDF]

Investigative and Clinical Urology
Purpose: To evaluate efficacy and safety of beta-3 adrenergic agonists in adults with neurogenic lower urinary tract dysfunction. Materials and Methods: According to a protocol (CRD42022350079), we searched multiple data sources for published and ...
Mohamed Medhat Elkhashab, Abdullah Mari Alqahtani, Myung Ha Kim, Jinu Kim, Jang Hwan Kim, Jae Hung Jung   +5 more
doaj   +1 more source