Comprehensive Physiology, Volume 15, Issue 2, April 2025.Pak1 regulates cardiac function, adipose tissue metabolism, and pancreatic β‐cell survival and function. Inflammation, oxidative stress, and Hippo signaling link Pak1 dysfunction across these tissues. Pak1 activators hold promise as potential therapeutic interventions. Images were created with a licensed version of BioRender.com.
Paola C. Rosas, R. John Solaro
wiley +1 more source
Baicalin Prevents Chronic β-AR Agonist-Induced Heart Failure via Preventing Oxidative Stress and Overactivation of the NADPH Oxidase NOX2. [PDF]
J Cell Mol MedGe Y +6 more
europepmc +1 more source
Ecology and Evolution, Volume 15, Issue 4, April 2025.Multi‐omics analysis of gut microbiome and host metabolism in different populations of Chinese alligators (Alligator sinensis) during various reintroduction phases. ABSTRACT Reintroduction plays a significant role in the self‐maintenance and reconstruction of wild animal populations, serving as a communication bridge between captive and wild animals ...
Chong Wang +8 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
In vivo regulation of beta-adrenergic receptors on mononuclear leukocytes and heart. Assessment of receptor compartmentation after agonist infusion and acute aortic constriction in guinea pigs. [PDF]
, 1988 Alan S. Maisel +4 more
openalex +1 more source
Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial
ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad +9 more
wiley +1 more source
Beta-3 Adrenoceptor Agonism Protects the Enteric Nervous Tissue Against Hyperoxia-Induced Damage. [PDF]
CellsNardini P +6 more
europepmc +1 more source
Rat cardiac muscle single cell automaticity responses to alpha- and beta-adrenergic agonists and antagonists. [PDF]
, 1982 Kent Hermsmeyer +3 more
openalex +1 more source
Exploration, Volume 5, Issue 2, April 2025.The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang +7 more
wiley +1 more source
Exploring the Therapeutic Potential of Mitragynine and Corynoxeine: Kratom-Derived Indole and Oxindole Alkaloids for Pain Management. [PDF]
Pharmaceuticals (Basel)Alford AS +4 more
europepmc +1 more source