Results 131 to 140 of about 38,715 (223)

Effects of Opioids, Benzodiazepines, Gabapentinoids, and Antidepressants on Fracture Risk in Alcohol‐Related Cirrhosis

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background Patients with alcohol‐related liver cirrhosis (ALD cirrhosis) have an increased risk of falls and fractures. Opioids, benzodiazepines, gabapentinoids, and antidepressants are known to increase fall risk. Aims We aimed to determine the effects of opioids, benzodiazepines, gabapentinoids, and antidepressants on fracture risk in ALD ...
Frederik Kraglund, Thomas Deleuran, Marie Aarup Storgaard, Eva Sædder, Peter Jepsen   +4 more
wiley   +1 more source

Lipid metabolic reprogramming in the tumor microenvironment and its mechanistic role in immunosuppressive cells. [PDF]

Front Immunol
Liu W, Wang Z, Li Z, Li S, Shi X, Xu Y, Wang J.   +6 more
europepmc   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Pharmacological treatment of obsessive-compulsive disorder in children and adolescents: An overview. [PDF]

World J Clin Pediatr
Rajalakshmi AK, Pawar AKS, Baweja R.
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming. [PDF]

World J Clin Oncol
Li ZK, Liao JL, Luo MR, Fang SJ, Huang WZ, Zhang DY.   +5 more
europepmc   +1 more source

How does type 2 diabetes modify the risk of Alzheimer's disease?

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vascular or AD neuropathological changes, and mechanistic hypotheses include central insulin resistance and ...
G. T. Sutherland, A. Chen, H‐T. Nguyen‐Hao, H. Mundell, E. Aladyeva, M. J. Hofer, O. Harari, S. M. Twigg   +7 more
wiley   +1 more source

Special Issue "Neuropharmacology of Plant Extracts and Their Active Compounds". [PDF]

Pharmaceuticals (Basel)
Alonso-Castro AJ.
europepmc   +1 more source

The Immune Landscape of Acral Melanoma: From Basic to Clinical

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Acral melanoma (AM) is an aggressive melanoma subtype with poor prognosis and limited response to immune checkpoint inhibitors (ICIs). Despite increasing research efforts, the mechanisms underlying therapeutic resistance remain incompletely understood.
Lihong Jiang, Zhaotian Zhang
wiley   +1 more source

The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes. [PDF]

Front Clin Diabetes Healthc
Christoffersson G, Muntjewerff EM.
europepmc   +1 more source