PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors
Frontiers in Cell and Developmental Biology, 2015 Cyclic-AMP (cAMP)-dependent protein kinase (PKA) is the main effector of cAMP signaling in all tissues. Inactivating mutations of the PRKAR1A gene, coding for the type 1A regulatory subunit of PKA, are responsible for Carney complex and primary pigmented
Annabel Sophie Berthon +2 more
doaj +2 more sources
Adrenocortical Carcinoma [PDF]
Cancers, 2021 Adrenocortical carcinoma (ACC) is an extremely rare disease, the incidence of which is 0 [...]
Berruti A., Tiberio G. A. M., Sigala S.
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Central Adrenal Insufficiency Developing After Right Partial Nephrectomy Involving Ectopic Adrenocortical Adenoma Mimicking Right Renal Carcinoma and a Retrospective Diagnosis of Adrenal Cushing's Syndrome: A Case Report. [PDF]
IJU Case RepABSTRACT Introduction Ectopic adrenocortical adenomas that produce adrenal hormones and mimic renal cell carcinoma are extremely rare. Case Presentation A 49‐year‐old woman underwent partial nephrectomy of the upper pole of the kidney following a clinical diagnosis of renal cell carcinoma.
Arinami K +8 more
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Adrenocortical Adenocarcinoma in a Syrian Golden Hamster (Mesocricetus auratus) With Suspected Hyperadrenocorticism. [PDF]
Vet Med SciA 2‐year‐old female golden hamster presented with non‐pruritic alopecia of the hindquarters. Diagnostic imaging and cytological evaluation revealed a unilateral adrenal mass consistent with an adrenocortical tumour, while biochemical analyses suggested corticosteroid secretion.
Billaux MF +6 more
europepmc +2 more sources
Biomedicines, 2021 Adrenocortical carcinoma (ACC) is a heterogenous group of diseases with different clinical behaviour between adult and paediatric patients. In addition, three histological variants, oncocytic, myxoid and sarcomatoid are noted on the recent World Health ...
A. Lam
semanticscholar +1 more source
Adrenocortical Carcinoma [PDF]
Endocrine Reviews, 2013 AbstractAdrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable prognosis. Here we summarize the knowledge about diagnosis, epidemiology, pathophysiology, and therapy of ACC. Over recent years, multidisciplinary clinics have formed and the first international treatment trials have been conducted.
Tobias, Else +9 more
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PD-1 Blockade in Advanced Adrenocortical Carcinoma.
Journal of Clinical Oncology, 2020 PURPOSE Adrenocortical carcinomas (ACC) are rare and aggressive malignancies with limited treatment options. This study was undertaken to evaluate the immunogenicity of ACC.
N. Raj +16 more
semanticscholar +1 more source
Emotional and Adrenocortical Responses of Infants to the Strange Situation: The Differential Function of Emotional Expression [PDF]
, 1998 The aim of the study was to investigate biobehavioural organisation in infants with different qualities of attachment. Quality of attachment (security and disorganisation), emotional expression, and adrenocortical stress reactivity were investigated in a
Ainsworth, M.D.S. +15 more
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Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
Comprehensive Physiology, 2016 The hypothalamo‐pituitary‐adrenocortical (HPA) axis is required for stress adaptation. Activation of the HPA axis causes secretion of glucocorticoids, which act on multiple organ systems to redirect energy resources to meet real or anticipated demand ...
James P. Herman +7 more
semanticscholar +1 more source
Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]
, 2020 Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian +14 more
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