Results 61 to 70 of about 8,531 (170)

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 3-16, August 2026.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Hypercortisolism: An Under‐Recognised Pathway Linked to Multi‐System Complications

Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 60-71, August 2026.
ABSTRACT The clinical understanding of hypercortisolism (HC) has evolved from a classic overt syndrome with florid Cushingoid features to a broader spectrum of disease that includes milder presentations, often referred to as mild autonomous cortisol secretion (MACS).
Hernan Daniel Sacoto, Vivian A. Fonseca
wiley   +1 more source

FOXA1 is a highly sensitive diagnostic marker for prostate cancer including small cell carcinoma of the prostate

Histopathology, Volume 89, Issue 2, Page 240-250, August 2026.
FOXA1 is a highly sensitive diagnostic marker for prostate cancer. Besides prostatic adenocarcinoma, it is also expressed in 57%–80% of metastatic or primary prostatic small cell carcinomas, which lose traditional prostatic markers including NKX3.1. Although it is less specific than NKX3.1, it can serve as a valuable adjunct for confirming prostatic ...
Jianping Zhao, Jun Yao, Hossein Hosseini, Ezra Baraban, Ruihe Lin, Charles C. Guo, Lei Huo, Wei Lu, Khaja Khan, Shufang Wang, Luisa Maren Solis Soto, Qingqing Ding   +11 more
wiley   +1 more source

Primary pigmented nodular adrenocortical disease presenting with a unilateral adrenocortical nodule treated with bilateral laparoscopic adrenalectomy: a case report

Journal of Medical Case Reports, 2010
Introduction Primary pigmented nodular adrenocortical disease is a rare cause of adrenocorticotropic hormone-independent Cushing's syndrome. We report an uncommon primary pigmented nodular adrenocortical disease case presenting with a unilateral ...
Kaltsas Gregory, Chrysikos Dimosthenis T, Markou Athina, Avlonitis Spiros, Pappa Theodora, Zografos George N, Aggeli Chrysanthi, Piaditis George   +7 more
doaj   +1 more source

Rolf Christian Gaillard (1944–2011): A builder of modern European endocrinology and neuroendocrinology

Journal of Neuroendocrinology, Volume 38, Issue 8, August 2026.
Abstract Rolf Christian Gaillard was a Swiss physician, scientist, and academic leader whose career contributed significantly to the development of modern European endocrinology and neuroendocrinology. Among his most remarkable qualities was an exceptional talent for organisation and institution‐building.
Philippe Chanson, Eduardo Spinedi, François Pralong   +2 more
wiley   +1 more source

Synchronous aldosterone- and cortisol-producing adrenocortical adenomas diagnosed using CYP11B immunohistochemistry

SAGE Open Medical Case Reports, 2019
Immunohistochemistry with antibodies targeting enzymes responsible for the final conversion steps of cortisol (CYP11B1) and aldosterone (CYP11B2) is gaining ground as an adjunct tool in the postoperative evaluation of adrenocortical nodules.
Adam Stenman, Ivan Shabo, Annica Ramström, Jan Zedenius, Carl Christofer Juhlin   +4 more
doaj   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, Volume 293, Issue 13, Page 3991-4013, July 2026.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Outcomes and opportunities: evaluating an unselected cohort of patients with adrenal incidentaloma at a tertiary hospital in New Zealand

Internal Medicine Journal, Volume 56, Issue 7, Page 1157-1165, July 2026.
Abstract Background The prevalence of adrenal incidentalomas is increasing, along with the incidence of functional or malignant lesions. This study assessed how imaging of adrenal incidentalomas at a tertiary hospital in Auckland, New Zealand, without a dedicated adrenal incidentaloma service, conformed to the American College of Radiology (ACR ...
Anthony Benfell, Liam Quinlan, Kunj Joshi, Tej Joshi, Shekhar Sehgal   +4 more
wiley   +1 more source

Single‐nucleus and spatial transcriptome reveal adrenal homeostasis in normal and tumoural adrenal glands

Clinical and Translational Medicine
The human adrenal gland is a complex endocrine tissue. Studies on adrenal renewal have been limited to animal models or human foetuses. Enhancing our understanding of adult human adrenal homeostasis is crucial for gaining insights into the pathogenesis ...
Barbara Altieri, A. Kerim Secener, Somesh Sai, Cornelius Fischer, Silviu Sbiera, Panagiota Arampatzi, Stefan Kircher, Sabine Herterich, Laura‐Sophie Landwehr, Sarah N. Vitcetz, Caroline Braeuning, Martin Fassnacht, Cristina L. Ronchi, Sascha Sauer   +13 more
doaj   +1 more source

Hypercortisolism and primary aldosteronism caused by bilateral adrenocortical adenomas: a case report

BMC Endocrine Disorders, 2019
Background Co-existing Cushing’s syndrome and primary aldosteronism caused by bilateral adrenocortical adenomas, secreting cortisol and aldosterone, respectively, have rarely been reported.
Kaiyun Ren, Jia Wei, Qilin Liu, Yuchun Zhu, Nianwei Wu, Ying Tang, Qianrui Li, Qianying Zhang, Yerong Yu, Zhenmei An, Jing Chen, Jianwei Li   +11 more
doaj   +1 more source