Results 31 to 40 of about 18,670 (220)

Amylin: Localization, Effects on Cerebral Arteries and on Local Cerebral Blood Flow in the Cat

open access: yesThe Scientific World Journal, 2001
Amylin and adrenomedullin are two peptides structurally related to calcitonin gene-related peptide (CGRP). We studied the occurrence of amylin in trigeminal ganglia and cerebral blood vessels of the cat with immunocytochemistry and evaluated the role of ...
Lars Edvinsson   +2 more
doaj   +1 more source

Apocrine glands in the eyelid of primates contribute to the ocular host defense [PDF]

open access: yes, 2004
Apocrine glands of Moll are regular components of primate eyelids. We studied the distribution and localization of these glands in three different primate species, the common marmoset, the rhesus monkey, and the hamadryas baboon.
Stoeckelhuber, B. M.   +2 more
core   +1 more source

Adrenomedulline improves ischemic left colonic anastomotic healing in an experimental rodent model

open access: yesClinics, 2011
BACKGROUND: Leakage from colonic anastomosis is a major complication causing increased mortality and morbidity. Ischemia is a well-known cause of this event.
Oguzhan Karatepe   +5 more
doaj   +1 more source

Disturbed flow–induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis

open access: yesJCI Insight, 2020
Atherosclerosis develops preferentially in areas of the arterial system, in which blood flow is disturbed. Exposure of endothelial cells to disturbed flow has been shown to induce inflammatory signaling, including NF-κB activation, which leads to the ...
Akiko Nakayama   +9 more
doaj   +1 more source

Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)

open access: yesBiomolecules, 2020
Recently, the stabilization of the endothelium has been explicitly identified as a therapeutic goal in coronavirus disease 2019 (COVID-19). Adrecizumab (HAM8101) is a first-in-class humanized monoclonal anti-Adrenomedullin (anti-ADM) antibody, targeting ...
Mahir Karakas   +12 more
doaj   +1 more source

Adrenomedullin Expression Characterizes Leukemia Stem Cells and Associates With an Inflammatory Signature in Acute Myeloid Leukemia

open access: yesFrontiers in Oncology, 2021
Adrenomedullin (ADM) is a hypotensive and vasodilator peptide belonging to the calcitonin gene-related peptide family. It is secreted in vitro by endothelial cells and vascular smooth muscle cells, and is significantly upregulated by a number of stimuli. 
Giorgia Simonetti   +20 more
doaj   +1 more source

Adrenomedullin protects rat dorsal root ganglion neurons against doxorubicin-induced toxicity by ameliorating oxidative stress [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2020
Objective(s): Despite effective anticancer effects, the use of doxorubicin (DOX) is hindered due to its cardio and neurotoxicity. The neuroprotective effect of adrenomedullin (AM) was shown in several studies.
Amir Mahmoodazdeh   +4 more
doaj   +1 more source

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. [PDF]

open access: yes, 2005
BackgroundDeregulation of the Wnt/ beta-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues. Mutations in components of this pathway result in beta-catenin stabilization and
Ashworth, Alan   +2 more
core   +3 more sources

Effect of intracerebroventricular (ICV) injection of adrenomedullin and its interaction with NPY and CCK pathways on food intake regulation in neonatal layer-type chicks

open access: yesPoultry Science
: Adrenomedullin has various physiological roles including appetite regulation. The objective of present study was to determine the effects of ICV injection of adrenomedullin and its interaction with NPY and CCK receptors on food intake regulation.
Maryam Soleymani Zahed   +2 more
doaj   +1 more source

Prognostic value of biomarkers after cardiopulmonary bypass in pediatrics: The prospective PANCAP study.

open access: yesPLoS ONE, 2019
ObjectiveTo assess the usefulness of procalcitonin, pro-adrenomedullin and pro-atrial natriuretic peptide as predictors of need for mechanical ventilation and postoperative complications (need for inotropic support and bacterial infection) in critically ...
Sara Bobillo-Perez   +7 more
doaj   +1 more source

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