Results 61 to 70 of about 18,670 (220)

Pro‐adrenomedullin associates with congestion in acute heart failure patients

ESC Heart Failure
Aim Congestion is a major determinant of outcomes in acute heart failure. Its assessment is complex, making sufficient decongestive therapy a challenge.
Benedikt N. Beer, Saman Keshtkaran, Caroline Kellner, Lisa Besch, Jonas Sundermeyer, Angela Dettling, Paulus Kirchhof, Stefan Blankenberg, Christina Magnussen, Benedikt Schrage   +9 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Adrenomedullin: A Novel Therapeutic for the Treatment of Inflammatory Bowel Disease

Biomedicines, 2021
Adrenomedullin (AM) is a bioactive peptide with various physiological functions, including vasodilation, angiogenesis, anti-inflammation, organ protection, and tissue repair.
Shinya Ashizuka, Toshihiro Kita, Haruhiko Inatsu, Kazuo Kitamura   +3 more
doaj   +1 more source

Adrenomedullin inhibits prostate cancer cell proliferation through a cAMP-independent autocrine mechanism [PDF]

, 2004
Adrenomedullin (AM) is a multifunctional peptide expressed in the normal and malignant prostate, and in prostate cancer cells. To elucidate the potential role of AM in prostate cancer, we have transfected the human AM gene into PC-3, DU 145, and LNCaP ...
Abasolo, I. (Ibane), Calvo, A. (Alfonso), Montuenga-Badia, L.M. (Luis M.), Wang, Z. (Zhou)   +3 more
core   +1 more source

Integrating gepants into clinical practice for the acute treatment of migraine

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To assess the role of small‐molecule calcitonin gene–related peptide receptor antagonists (gepants) in the acute treatment of migraine, particularly in relation to triptan treatments. Background Triptans have established efficacy and are widely prescribed for the acute treatment of migraine.
Richard B. Lipton, David W. Dodick, Linda Davis, Stephanie J. Nahas, Peter J. Goadsby   +4 more
wiley   +1 more source

Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation [PDF]

, 1998
BACKGROUND/AIMS: Peripheral arterial vasodilation may be the key factor in the sodium and water retention of cirrhosis. The mechanism responsible for this vasodilation remains to be fully elucidated.
Andrade, A. (Amalia), Cuttitta, F. (Frank), Elssasser, T. (T.), Fernandez-Rodriguez, C.M. (Conrado M.), Montuenga-Badia, L.M. (Luis M.), Moreiras, M. (Mercedes), Prada, I. (Ignacio R.), Prieto, J. (Jesús), Quiroga, J. (Jorge)   +8 more
core   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Inflammation: Complexity and significance of cellular and molecular responses

Journal of Acute Disease
Inflammation is a multifaceted cellular and molecular response triggered by injury, infection, or various pathological conditions. Serving as a protective defense mechanism, the inflammatory response involves clinical signs like redness, swelling, pain ...
Serdar Özdemir
doaj   +1 more source

Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

International Journal of Cardiology: Heart & Vasculature, 2019
Background: The assessment of acute heart failure (AHF) in patients with acute coronary syndrome (ACS) is challenging. This study tested whether measuring plasma adrenomedullin in patients admitted for ACS provides valuable information regarding the ...
Mattia Arrigo, Jiri Parenica, Eva Ganovska, Marie Pavlusova, Alexandre Mebazaa   +4 more
doaj   +1 more source