Results 91 to 100 of about 689,743 (389)

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Advancing adult learning in Eastern Europe and Central Asia [PDF]

This report presents available evidence on adult education and training in Europe and Central Asia (ECA), differentiating two separate types: continuing vocational education and training (CVET) for the employed, sought either by employers or individuals,
Bodewig, Christian, Hirshleifer, Sarojini   +1 more
core  

Leitprinzipien und didaktische Handlungsansätze in der Erwachsenenbildung. Lernen im Alter [PDF]

, 2011
Seit den 1960/70er Jahren ist eine veränderte Sichtweise auf das Lernen im Alter zu beo­bachten. Obwohl seit dieser Zeit das Defizit-Modell, demzufolge mit zunehmendem Lebensalter die Lernfähigkeit nachlässt, permanent widerlegt wird, existiert in der ...
Brünner, Anita
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Adults’ Educational Needs and Continuous Professional Development

The International Conference "The Risk in Contemporary Economy" (Dunarea de Jos University. Faculty of Economics), 2017
In order to decide on an education necessity, one has to answer the question What and who do we organize a certain educational process or system for and why do we organize it in a certain way and not otherwise? . In order to decide on an education necessity one must also answer the question What social problems does the educational process or system ...
Monica Raducan, Geanina Colan, Diamanta Bulai, Marilena Rapa   +3 more
openaire   +3 more sources

Review of The Handbook of Adult and Continuing Education, 2020 Edition

ADULT LITERACY EDUCATION: THE INTERNATIONAL JOURNAL OF LITERACY, LANGUAGE, AND NUMERACY, 2022
Jill Castek, Tyler Frank
semanticscholar   +1 more source

FORMER USM DVC-ICN DEDICATES ‘HALL OF FAME’ AWARD TO UNIVERSITY [PDF]

, 2016
PENANG, 6 December 2016 – The former Universiti Sains Malaysia (USM) Deputy ViceChancellor (Industry and Community Network), Dato’ Dr. Susie See Ching Mey dedicated her international award, the ‘International Adult and Continuing Education Hall of Fame’
MPRC, Pusat Media & Perhubungan Awam
core  

Teacher attitudes and best practices with ICT faculty Adult Continuing Education in Andalusia [PDF]

El presente artículo recoge los resultados de un estudio cuyo objetivo ha sido determinar las actitudes del profesorado de educación permanente de adultos de la comunidad autónoma de Andalucía, hacia el uso e integración de las Tecnologías de la ...
Fernández Batanero, Jose María, Torres González, José Antonio   +1 more
core   +2 more sources

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source