Results 81 to 90 of about 704,290 (266)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

ОБЩЕСТВЕННЫЕ (КОМЬЮНИТИ) КОЛЛЕДЖИ КАК СОСТАВЛЯЮЩАЯ СИСТЕМЫ ВЫСШЕГО ОБРАЗОВАНИЯ США [PDF]

, 2018
У статті схарактеризовано особливості громадських (комм’юніті) коледжів США як складової системи США. З’ясовано, що громадські (комм’юніті) коледжі зорієнтовані, насамперед, на задоволення потреб місцевої громади та співпрацю з нею, через підготовку ...
Братко, Марія Василівна
core  

A European lens upon adult and lifelong learning in Asia [PDF]

, 2017
In this article, we seek to assess the extent to which adult and lifelong learning policies and practices in Asia have distinctiveness by comparison to those found in western societies, through an analysis of inter-governmental, national and regional ...
A Fejes, A Ogawa, C-Y Wang, Commission of the European Union, Commission of the European Union, Commission of the European Union, D-F Chang, E Faure, EA Hanushek, European Commission, European Commission, F Sandberg, Government of India Planning Commission, J Allemendinger, J Jacobs, J Yang, J Yang, JI Byun, JP Heisig, K Maclachlan, K Sankey, Katarzyna Borkowska, L Millie, L Yorks, M Houston, M Osborne, M Osborne, M Pilz, Michael Osborne, Ministry of Higher Education, MJD Mwaikokesya, N Dhirathiti, N Longworth, National Institute for Lifelong Education & UNESCO Institute for Lifelong Learning (NILE/UIL), OECD, P Jarvis, P Kearns, P Raggett, Q Sun, R Faris, R Faris, S Han, S Kim, Shanghai Municipal Institute for Lifelong Education (SMILE), T Eckert, T Husén, T Husén, UNESCO, Y Kee, Z Zhang   +49 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Advancing adult learning in Eastern Europe and Central Asia [PDF]

This report presents available evidence on adult education and training in Europe and Central Asia (ECA), differentiating two separate types: continuing vocational education and training (CVET) for the employed, sought either by employers or individuals,
Bodewig, Christian, Hirshleifer, Sarojini   +1 more
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

The quality and relevance of staff training to deliver adult basic education (ABE) and English for speakers of other languages (ESOL) [PDF]

, 2010
"This report is published in response to a request in the annual Ministerial remit to Estyn for 2009-2010 to evaluate the quality and relevance of staff training to deliver ABE and ESOL...

core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

The influence of professional development on quality teaching in Ghanaian pre-tertiary schools

Social Sciences and Humanities Open
Teacher professional development (TPD) has garnered increasing global attention and significant financial investments in recent years, yet empirical studies examining its direct influence on teaching quality remain scarce.
Inusah Salifu, Faisal Iddris, Yaw Owusu-Agyeman, Samuel Nuamah Eshun   +3 more
doaj   +1 more source

Engagement of older adults in higher education: International perspectives from New Zealand and Scotland [PDF]

, 2012
This article explores the issue of older adults’ access to and participation in higher education in two countries, Aotearoa New Zealand and Scotland. It discusses older adults’ engagement with regard to patterns of participation and provision, using a ...
Findsen, Brian
core   +1 more source