Results 61 to 70 of about 704,290 (266)

Superhuman? Perceptions of accelerated students and graduates working in health care [PDF]

, 2014
Background: Accelerated university courses were developed in response to consumer demand and educational advances, yet a lack of research exists related to the impact of accelerated health care courses in the United Kingdom.
American Association of Colleges of Nursing, American Association of Colleges of Nursing, Bentley, Blythe, Caldwell, Cangelosi, Cangelosi, Cangelosi, Chartered Society of Physiotherapy, Craik, Glasgow Caledonian University, Grounds, Halkett, Health Professions Council, Howkins, Husson, James Milligan, Kasworm, Kohn, Meyer, Miklancie, Neill, Neill, Nursing and Midwifery Council, Oermann, Ouellet, Quality Assurance Agency for Higher Education, Scott, Seifert, Seldomridge, Smith, Stewart, Swenson, Traub, Wilcock, Wilkinson, Wlodkowski, Wu, Youssef   +38 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

People's education - An Examination of the Concept [PDF]

, 1988
This research report sets out to examine the concept of People’s Education in South Africa from December 1985, when the call for People’s Education was first made, to September 19877“It is the result of a preliminary six month research project which set ...
Centre for Adult and Continuing Education (CACE)
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Teaching adult education history in a time of uncertainty and hope [PDF]

, 2010
Adult educations continuing purpose has been questioned by writers for over twenty years and today the re-organisation and closure of some University departments brings this issue to the fore. This paper takes up the theme of really useful knowledge in a
Brown, T
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Background Color Influences Consumer Evaluations: Is There a Product Contagion Effect?

Journal of Food Quality
The present study focuses on how the contagion effect between food products placed on different color backgrounds influences consumer evaluations, through a series of three experiments.
Li-Chin Shih, Hung-Chou Lin
doaj   +1 more source

Curriculum transformation in a South African open distance e-learning university: A firsthand account of stakeholder collaboration, challenges and pathways forward

Transformation in Higher Education
A collaborative approach to curriculum transformation (CT) ensures that higher education programmes remain inclusive, future-ready and responsive to societal needs.
Florah M. Teane
doaj   +1 more source

'Really on the ball': exploring the implications of teachers' PE-CPD experience [PDF]

, 2015
Continuing professional development (CPD) is currently high on the Scottish Education agenda. Recent curriculum reform in Scotland, with the introduction of Curriculum for Excellence, places physical education (PE) at the forefront for its role in ...
Campbell, T., Elliot, D.L.
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source