Results 91 to 100 of about 704,290 (266)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

高齡代言人對高齡者評估廣告之影響 Effects of Elderly Endorsers on Older Adults’ Advertising Evaluation

open access: yesJournal of Research in Education Sciences, 2018
本研究欲探討高齡者代言功能性與享樂性產品的廣告效果,並進一步加入代言人性別、知名度、國籍為調節變項。本研究歸納出四個研究目的:一、探討高齡代言人與產品配適對廣告效果之影響;二、探討高齡代言人性別是否會影響廣告效果;三、探討高齡代言人知名度是否會影響廣告效果;四、探討高齡代言人國籍是否會影響廣告效果。本研究採用實驗法,施測人數共 420 人。研究結果顯示:一、高齡代言人代言功能性產品的廣告效果會優於享樂性產品;二、無論在功能性產品或是享樂性產品的代言中,高齡代言人的性別不具有調節效果;三 ...
林鴻洲 Hung-Chou Lin   +1 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Integrating curriculum reform, faculty development, and graduate employability in South Africa’s higher education: a qualitative study in the Fourth Industrial Revolution

open access: yesCogent Education
The accelerating pace of the Fourth Industrial Revolution (4IR) compels higher education institutions (HEIs) to align curricula and faculty development with evolving labor market and societal needs.
Ivan Magadza
doaj   +1 more source

應用多媒體行動學習系統輔助大學生情緒管理學習成效與評量之探究 Exploration of Learning Effectiveness and Assessment of Emotion Management for College Students by Using a Multimedia Mobile Learning System

open access: yesJournal of Research in Education Sciences, 2014
本研究目的主要在分析運用多媒體行動學習系統結合課堂教學,以輔助大學生情緒管理的學習成效。多媒體行動學習系統是以Moodle 平台連結Android 智慧型手機,加上多媒體教材、即時簡訊、學習教材及Facebook互動論壇等功能模組所發展的情緒管理學習系統;同時,以多級模糊推論系統輔助大學生對情緒管理情境學習各階段的質性反思之學習評量。本研究採用準實驗設計法,對實驗組及對照組共72 位大學生進行教學實驗,並進行學習成效、系統滿意度及反思學習成效問卷的統計,研究結果發現:一 ...
張菀珍 Wan-Jen Chang   +1 more
doaj   +1 more source

Continuing midwifery education beyond graduation : student midwives' awareness of continuous professional development [PDF]

open access: yes, 2017
Midwifery education plays an important role in educating graduates about engaging in continuous professional development (CPD) but there is a lack of empirical research analysing student midwives’ awareness of CPD beyond graduation.
Embo, Mieke, Valcke, Martin
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

How do we best regulate youth work as a profession within the social services sector in South Africa

open access: yesInternational Journal of Adolescence and Youth
The professionalisation of youth work in South Africa has progressed through several stages, including hosting the 2nd Commonwealth Conference on Youth Work.
Thulani Andrew Chauke
doaj   +1 more source

Partners with clinical practice: Evaluating the student and staff experiences of on-line continuing professional development for qualified nephrology practitioners [PDF]

open access: yes, 2005
The inclusion of online learning technologies into the higher education (HE) curriculum is frequently associated with the design and development of new models of learning.
Hurst, J., Quinsee, S.
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

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