Results 51 to 60 of about 658,530 (361)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Life long learning in rural areas: a report to the Countryside Agency [PDF]
, 2002 Lifelong Learning is a broad umbrella term which includes many different kinds of provision and different forms of learning. At its heart is formal learning, often classroom based, or involving paper and electronic media, undertaken within educational ...
Cara, S. +7 more
core
FEBS Letters, EarlyView.Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston +7 more
wiley +1 more source
「情緒勒索量表」中文化之信效度分析 Development and Psychometric Analysis of an Emotional Blackmail Scale
Journal of Research in Education Sciences情緒勒索為一種情緒操縱的手段，透過引發被勒索者的負面感受來使其服從或妥協於自己的要求。此概念在近年受到大眾關注，但相關的學術研究卻較少，且多數集中在親密關係或組織管理相關領域中，對於親子關係間的情緒勒索議題討論則相對更少。最主要的原因乃是測量工具較為缺乏，因此，本研究主要目的在於發展評估親子關係間情緒勒索行為之量表，以期能提供此領域研究者合適的測量工具。本研究翻譯Karnani與Zelman（2019）所編修之20題版的情緒勒索量表，並要求參與者以主要照顧者為回憶對象進行情緒勒索經驗評估 ...
郭郡羽 Chun-Yu Kuo1 +2 more
doaj +1 more source
Implementing Adult Learning Principles to Overcome Barriers Of Learning in Continuing Higher Education Programs [PDF]
, 2010 A fundamental aspect to continuing higher education is overcoming of barriers of learning when dealing with non-traditional students. With non-traditional student enrollment on the rise, continuing higher education programs have an obligation to address ...
De Vito, Kristen M.
core +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Frontiers in Nutrition, 2021 Most of the previous studies with respect to message sidedness mainly focus on the effect of message sidedness in advertising on behavior of consumers and it is unknown how consumers respond to different message sidedness when a one-sided or two-sided ...
Hung-Chou Lin, Shih-Tse Wang
doaj +1 more source
What's new in Europe? Recent Trends in Adult and Continuing Education [PDF]
, 2008 Colleagues from various European countries were invited to an international lecture series at the University of Duisburg-Essen to talk about trends in adult and continuing education.
Egetenmeyer, Regina, Strauch, Anne
core +1 more source
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source