Results 81 to 90 of about 701,750 (333)

Technological literacy and its influence on teachers’ adoption of a blended learning approach

open access: yesReading & Writing
Background: The teachers in one sub-district in the North West province lacked technological knowledge and skills thus did not adopt a blended learning approach in their daily teaching.
Florah M. Teane
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Advancing adult learning in Eastern Europe and Central Asia [PDF]

open access: yes
This report presents available evidence on adult education and training in Europe and Central Asia (ECA), differentiating two separate types: continuing vocational education and training (CVET) for the employed, sought either by employers or individuals,
Bodewig, Christian   +1 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

高齡代言人對高齡者評估廣告之影響 Effects of Elderly Endorsers on Older Adults’ Advertising Evaluation

open access: yesJournal of Research in Education Sciences, 2018
本研究欲探討高齡者代言功能性與享樂性產品的廣告效果,並進一步加入代言人性別、知名度、國籍為調節變項。本研究歸納出四個研究目的:一、探討高齡代言人與產品配適對廣告效果之影響;二、探討高齡代言人性別是否會影響廣告效果;三、探討高齡代言人知名度是否會影響廣告效果;四、探討高齡代言人國籍是否會影響廣告效果。本研究採用實驗法,施測人數共 420 人。研究結果顯示:一、高齡代言人代言功能性產品的廣告效果會優於享樂性產品;二、無論在功能性產品或是享樂性產品的代言中,高齡代言人的性別不具有調節效果;三 ...
林鴻洲 Hung-Chou Lin   +1 more
doaj   +1 more source

FORMER USM DVC-ICN DEDICATES ‘HALL OF FAME’ AWARD TO UNIVERSITY [PDF]

open access: yes, 2016
PENANG, 6 December 2016 – The former Universiti Sains Malaysia (USM) Deputy ViceChancellor (Industry and Community Network), Dato’ Dr. Susie See Ching Mey dedicated her international award, the ‘International Adult and Continuing Education Hall of Fame’
MPRC, Pusat Media & Perhubungan Awam
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

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