Results 81 to 90 of about 669,521 (358)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

應用多媒體行動學習系統輔助大學生情緒管理學習成效與評量之探究 Exploration of Learning Effectiveness and Assessment of Emotion Management for College Students by Using a Multimedia Mobile Learning System

Journal of Research in Education Sciences, 2014
本研究目的主要在分析運用多媒體行動學習系統結合課堂教學，以輔助大學生情緒管理的學習成效。多媒體行動學習系統是以Moodle 平台連結Android 智慧型手機，加上多媒體教材、即時簡訊、學習教材及Facebook互動論壇等功能模組所發展的情緒管理學習系統；同時，以多級模糊推論系統輔助大學生對情緒管理情境學習各階段的質性反思之學習評量。本研究採用準實驗設計法，對實驗組及對照組共72 位大學生進行教學實驗，並進行學習成效、系統滿意度及反思學習成效問卷的統計，研究結果發現：一 ...
張菀珍 Wan-Jen Chang, 葉榮木 Zong-Mu Yeh   +1 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

屆退人員貢獻老化退休準備核心知能指標建構及其對退休準備教育的啟示 Constructing the Core Competence Indicators of Contributive Aging Retirement Preparation Among People Approaching Retirement and Its Implications for Retirement Preparation Education

Journal of Research in Education Sciences, 2019
本研究聚焦於「屆退人員貢獻老化退休準備核心知能指標之建構」，為我國即將退休的中高齡者建構一套系統化的貢獻老化退休準備核心知能指標，藉此探索出對退休準備教育的啟示。研究者採用半結構訪談與德懷術問卷調查法，蒐集退休人員繼續貢獻社會的意願、途徑 及應具備的退休準備核心知能等資料，進行質性與量化的分析，以建構出「屆退人員貢獻老化退休準備核心知能指標」。研究結果歸納出屆退人員貢獻老化退休準備核心知能指標，包括四個向度：貢獻意願、貢獻障礙、貢獻準備及貢獻途徑；八個構面：內在原因、外在原因、個人障礙、環境障礙 ...
胡夢鯨 Meng-Ching Hu , 王怡分 Yi-Fen Wang   +1 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Supporting Students with Specific Learning Needs in Mathematics Teaching and Learning: A Case Study of Five Secondary Schools in the OR Tambo Coastal District, Eastern Cape, South Africa [PDF]

Journal of Education and Learning Technology
Supporting students with specific learning needs in mathematics requires a multifaceted approach. Research has shown that students with learning disabilities, including those at risk or low-achieving, benefit from tailored interventions in mathematics ...
Thabisa Maqoqa , Mqondiso Andrea Buka
doaj   +1 more source

Adults’ Educational Needs and Continuous Professional Development

The International Conference "The Risk in Contemporary Economy" (Dunarea de Jos University. Faculty of Economics), 2017
In order to decide on an education necessity, one has to answer the question What and who do we organize a certain educational process or system for and why do we organize it in a certain way and not otherwise? . In order to decide on an education necessity one must also answer the question What social problems does the educational process or system ...
Monica Raducan, Geanina Colan, Diamanta Bulai, Marilena Rapa   +3 more
openaire   +3 more sources

Review of The Handbook of Adult and Continuing Education, 2020 Edition

ADULT LITERACY EDUCATION: THE INTERNATIONAL JOURNAL OF LITERACY, LANGUAGE, AND NUMERACY, 2022
Jill Castek, Tyler Frank
semanticscholar   +1 more source