Results 121 to 130 of about 116,589 (255)
Advanced Glycation End Products: Building on the Concept of the "Common Soil" in Metabolic Disease.
Endocrinology, 2019 The role of advanced glycation end products (AGEs) in promoting and/or exacerbating metabolic dysregulation is being increasingly recognized. AGEs are formed when reducing sugars non-enzymatically bind to proteins or lipids, a process that is enhanced by
Henry H. Ruiz, R. Ramasamy, A. Schmidt
semanticscholar +1 more source
One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
core +1 more source
An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum [PDF]
, 2020 Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1.
Ekremoğlu, Murat +4 more
core +3 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Chronic deposits of advanced glycation end products produced by enzymatic glycation have been suggested as predictors of atherosclerotic‐related disorders.
Ivan Cavero‐Redondo +7 more
doaj +1 more source
DJ-1 as a deglycating enzyme: A unique function to explain a multifaceted protein? [PDF]
, 2017 The recently reported deglycating activity of DJ-1 reconciles several features previously described for the protein. The deglycating activity reported for DJ-1 may explain its different subcellular localizations, indeed the protein has been found in the ...
Bisaglia, Marco, DE LAZZARI, Federica
core +2 more sources
Involvement of Advanced Glycation End Products in the Pathogenesis of Diabetic Retinopathy
Cellular Physiology and Biochemistry, 2018 Diabetic retinopathy (DR) is a common and devastating microvascular complication of diabetes and a major cause of acquired blindness in young adults. Advanced glycation end products (AGEs) accumulated under hyperglycemic conditions are thought to play an
Jing Xu +6 more
semanticscholar +1 more source
Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]
, 2014 Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo +3 more
core +1 more source
Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers [PDF]
, 2012 Advanced glycation end-products, namely AGEs, are involved in the pathogenesis of numerous diseases. If AGEs inhibitors are well-known, only few products are described as compounds able to destroy those deleterious products.
D. Seraphin +6 more
core +3 more sources
Advanced glycation end-products and bone fractures [PDF]
IBMS BoneKEy, 2009 Bone does not turn over uniformly, and becomes susceptible to post-translational modification by non-enzymatic glycation (NEG). NEG of bone causes the formation of advanced glycation end-products (AGEs) and this process is accelerated with aging, diabetes and antiresorptive postmenopausal osteoporosis therapy.
openaire +2 more sources
Journal of Biological Research, 2018 The interaction of Advanced Glycation End products (AGEs) and their specific receptor, Receptor for Advanced Glycation End products (RAGE) play an important role in diabetes and vascular complications.
Claudia Borsa +4 more
doaj +1 more source