Results 31 to 40 of about 116,589 (255)

Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived Fibroblasts [PDF]

, 2019
Debilitating cases of tendon pain and degeneration affect the majority of diabetic individuals. The high rate of tendon degeneration persists even when glucose levels are well controlled, suggesting that other mechanisms may drive tendon degeneration in ...
Cannon, Jason R., Carroll, Chad C., Foguth, Rachel, Kuang, Shihuan, Patel, Shivam H., Sabbaghi, Arman, Saw, Shannon K., Shannahan, Jonathan H., Yue, Feng   +8 more
core   +2 more sources

Association of advanced glycation end products in Dupuytren disease

Journal of Orthopaedic Surgery and Research, 2018
Background Advanced glycation end products are associated with aging, hyperglycemia, and oxidative stress. Accumulation of advanced glycation end products can cause various pathological conditions; however, the association of Dupuytren’s disease with ...
Fumiaki Takase, Yutaka Mifune, Atsuyuki Inui, Yasuhiro Ueda, Takeshi Kataoka, Takeshi Kokubu, Ryosuke Kuroda   +6 more
doaj   +1 more source

A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer. [PDF]

PLoS ONE, 2018
Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function.
Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, Björn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt   +9 more
doaj   +1 more source

Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts

Translational Oncology, 2022
The molecular implications of food consumption on cancer etiology are poorly defined. The rate of nutrition associated non-enzymatic glycoxidation, a reaction that occurs between reactive carbonyl groups on linear sugars and nucleophilic amino, lysyl and
Bradley A. Krisanits, Pamela Woods, Lourdes M. Nogueira, Demarcus D. Woolfork, Courtney E. Lloyd, Andrew Baldwin, Callan C. Frye, Kendell D. Peterson, Sean D. Cosh, Qi-Jin Guo, Laura S. Spruill, Michael B. Lilly, Kristi Helke, Hong Li, George S. Hanna, Mark T. Hamann, Courtney Thomas, Mahtabuddin Ahmed, Monika B. Gooz, Victoria J. Findlay, David P. Turner   +20 more
doaj   +1 more source

NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification [PDF]

, 2005
The non-enzymatic reaction between reducing sugars and long-lived proteins in vivo results in the formation of glycation and advanced glycation end products, which alter the properties of proteins including charge, helicity, and their tendency to ...
Howard, Mark J., Smales, Christopher Mark   +1 more
core   +1 more source

Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue [PDF]

, 2017
Concurrent with a progressive loss of regenerative capacity, connective tissue aging is characterized by a progressive accumulation of Advanced Glycation End-products (AGEs).
Andreassen, Ansari, Avery, Bailey, Bedi, Cheng, Del Turco, Dressler, Dyer, Fessel, Fessel, Fessel, Fratzl, Gautieri, Gautieri, Gautieri, Goh, Goh, Grandhee, Gupta, Hansen, Kraft, Lavagnino, Li, Li, Meier, Monnier, Nagaraj, Nair, Reddy, Reigle, Rigoldi, Sasaki, Schnider, Sell, Sell, Sensi, Slatter, Snedeker, Sroga, Su, Su, Svensson, Svensson, Szczesny, Szczesny, Tanaka, Tang, Tang, Thorpe, Toyama, Vashishth, Verzijl, Verzijl, Vesentini, Vincent, Willett, Wu, Yamagishi, Zimmermann   +59 more
core   +2 more sources

Soluble levels of receptor for advanced glycation endproducts and dysfunctional high-density lipoprotein in persons infected with human immunodeficiency virus: ACTG NWCS332. [PDF]

, 2018
The role of high-density lipoprotein (HDL) function and advanced glycation end products (AGEs) in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear.
Aberg, Judith A, Currier, Judith S, Danoff, Ann, Kelesidis, Theodoros, Kendall, Michelle A, Schmidt, Ann Marie   +5 more
core   +1 more source

Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases

Molecules, 2022
As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high ...
Qing Yue, Yu Song, Zi Liu, Lin Zhang, Ling Yang, Jinlong Li   +5 more
semanticscholar   +1 more source

Pharmacologic approaches against advanced glycation end products (ages) in diabetic cardiovascular disease [PDF]

, 2015
Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients.
Avtaar Singh, Sanjeet Singh, Chello, Massimo, DI DOMENICO, Fabio, Nappi, Francesco, Nenna, Antonio, Spadaccio, Cristiano, Sutherland, Fraser W   +6 more
core   +2 more sources

Advanced glycation end products promote osteoporosis by inducing ferroptosis in osteoblasts

Molecular Medicine Reports, 2022
Advanced glycation end products (AGEs) have been widely reported to play an important role in osteoporosis (OP), particularly in diabetes-related OP.
Weiwei Ge, Jian Jie, Jie Yao, Wei Li, Yahui Cheng, W. Lu   +5 more
semanticscholar   +1 more source