Results 41 to 50 of about 81,199 (355)

A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer. [PDF]

PLoS ONE, 2018
Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function.
Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, Björn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt   +9 more
doaj   +1 more source

Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts

Translational Oncology, 2022
The molecular implications of food consumption on cancer etiology are poorly defined. The rate of nutrition associated non-enzymatic glycoxidation, a reaction that occurs between reactive carbonyl groups on linear sugars and nucleophilic amino, lysyl and
Bradley A. Krisanits, Pamela Woods, Lourdes M. Nogueira, Demarcus D. Woolfork, Courtney E. Lloyd, Andrew Baldwin, Callan C. Frye, Kendell D. Peterson, Sean D. Cosh, Qi-Jin Guo, Laura S. Spruill, Michael B. Lilly, Kristi Helke, Hong Li, George S. Hanna, Mark T. Hamann, Courtney Thomas, Mahtabuddin Ahmed, Monika B. Gooz, Victoria J. Findlay, David P. Turner   +20 more
doaj   +1 more source

Advanced glycation end products promote osteoporosis by inducing ferroptosis in osteoblasts

Molecular Medicine Reports, 2022
Advanced glycation end products (AGEs) have been widely reported to play an important role in osteoporosis (OP), particularly in diabetes-related OP.
Weiwei Ge, Jian Jie, Jie Yao, Wei Li, Yahui Cheng, W. Lu   +5 more
semanticscholar   +1 more source

Advanced Glycation End Products, Soluble Receptor for Advanced Glycation End Products, and Risk of Colorectal Cancer [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2011
Abstract Background: Advanced glycation end products (AGE) accumulate in human tissue proteins during aging, particularly under hyperglycemia conditions. AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE–ligand engagement ...
Stephanie J. Weinstein, Philip R. Taylor, Jarmo Virtamo, Barry I. Graubard, Demetrius Albanes, Li Jiao, Rachael Z. Stolzenberg-Solomon   +6 more
openaire   +3 more sources

Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases

Molecules, 2022
As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high ...
Qing Yue, Yu Song, Zi Liu, Lin Zhang, Ling Yang, Jinlong Li   +5 more
semanticscholar   +1 more source

Advanced Glycation End Products and Receptor for Advanced Glycation End Products in AA Amyloidosis

The American Journal of Pathology, 2003
Advanced glycation end products (AGEs) may be involved in either amyloidogenesis or complications related to amyloid. We hypothesized that AGEs may influence the pathogenesis of AA amyloidosis, and investigated the spatial and temporal relationship between AGEs, carboxy methyl lysine (CML), the AGE receptor (RAGE), and AA amyloid in humans and mice ...
Sophie Mansfeld, B. Stix, Christoph Röcken, Frank Bühling, Kay Stubenrauch, Bernd Weigle, Mona Schwan, Wolfgang Saeger, Rosemarie Kientsch-Engel   +8 more
openaire   +3 more sources

Skin advanced glycation end-products evaluation in infants according to the type of feeding and mother’s smoking habits

SAGE Open Medicine, 2016
Objectives: This study was conducted to assess whether formula-fed infants had increased skin advanced glycation end-products compared with breastfed ones.
Giovanni Federico, Martina Gori, Emioli Randazzo, Francesco Vierucci   +3 more
doaj   +1 more source

Accumulation of Advanced Glycation End-Products in the Body and Dietary Habits

Nutrients, 2022
The formation of advanced glycation end-products (AGE) in tissues is a physiological process; however, excessive production and storage are pathological and lead to inflammation.
A. Zawada, Alicja Machowiak, A. Rychter, A. Ratajczak, A. Szymczak-Tomczak, A. Dobrowolska, I. Krela-kaźmierczak   +6 more
semanticscholar   +1 more source

Dietary Advanced Glycation End Products and Aging [PDF]

Nutrients, 2010
Advanced glycation end products (AGEs) are a heterogeneous, complex group of compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino acids in proteins and other macromolecules. This occurs both exogenously (in food) and endogenously (in humans) with greater concentrations found in older adults.
Karen Chapman-Novakofski, Claudia Luevano-Contreras   +1 more
openaire   +3 more sources

Leukocytes in type 1 diabetes mellitus: the changes they undergo and induce

Біологічні студії, 2022
As leukocytes represent cellular and humoral immunity at the same time, they are a vital part of every immune process. This also stands for autoimmune processes and disorders, such as diabetes, specifically type 1 diabetes mellitus.
О. М. Kuchurka, М. O. Chaban, O. V. Dzydzan, I. V. Brodyak, N. O. Sybirna   +4 more
doaj   +1 more source